Cancer risk in hospitalized sarcoidosis patients: a follow-up study in Sweden
Cancer risk in hospitalized sarcoidosis patients: a follow-up study in Sweden
复制标题
DOI：
10.1093/annonc/mdn767
复制
发表时间：
2009-06-01
影响因子：
50.5
通讯作者：
Hemminki, K.
中科院分区：
文献类型：
--
作者：
Ji, J.;Shu, X.;Hemminki, K.
背景：结节病患者表现为免疫功能失调，可能与继发癌症有关。我们在这里检查了因结节病住院的瑞典受试者的总体和特定癌症风险。方法：通过从瑞典医院出院登记簿中识别住院结节病患者并将其与癌症登记处联系起来，建立了结节病研究数据库。计算结节病患者与非结节病患者的标准化发病率比（SIRs）。结果：1964 ~ 2004年，本院收治结节病患者10037例。其中1045名患者发生了后续癌症，随访1年后诊断为癌症的总体SIR为1.40,1.18。在皮肤（鳞状细胞）、肾脏和非甲状腺内分泌肿瘤以及非霍奇金淋巴瘤和白血病中发现了明显的过量。多次住院的患者风险较高。结论：结节病患者的总体癌症发病率超过40%，但增加主要局限于住院后的第一年。然而，皮肤癌、非霍奇金淋巴瘤和白血病的风险增加，特别是那些多次住院或老年住院的人，需要引起临床注意。
Background: Sarcoidosis patients show dysregulated immune function, which may be related to subsequent cancer. We examined here the overall and specific cancer risks among Swedish subjects who had been hospitalized for sarcoidosis.Methods: A sarcoidosis research database was created by identifying hospitalized sarcoidosis patients from the Swedish Hospital Discharge Register and by linking them with the Cancer Registry. Standardized incidence ratios (SIRs) were calculated for cancers in sarcoidosis patients compared with subjects without sarcoidosis.Results: A total of 10 037 patients were hospitalized for sarcoidosis during years 1964-2004. Among them 1045 patients developed subsequent cancer, giving an overall SIR of 1.40 and 1.18 for cancer diagnosed later than 1 year of follow-up. A significant excess was noted for skin (squamous cell), kidney and nonthyroid endocrine tumors and additionally for non-Hodgkin's lymphoma and leukemia. Patients with multiple hospitalizations showed high risks.Conclusions: A 40% overall excess incidence of cancer was noted among sarcoidosis patients, but the increase was confined mainly to the first year after hospitalization. However, the increased risks of skin cancer and non-Hodgkin's lymphoma and leukemia, especially for those with multiple hospitalizations or hospitalized at old age, call for clinical attention.