Stool-Based Pathogen Detection Offers Advantages as an Outcome Measure for Water, Sanitation, and Hygiene Trials
Stool-Based Pathogen Detection Offers Advantages as an Outcome Measure for Water, Sanitation, and Hygiene Trials
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DOI：
10.4269/ajtmh.19-0639
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发表时间：
2020-02-01
影响因子：
3.3
通讯作者：
Cumming, Oliver
中科院分区：
文献类型：
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作者：
Brown, Joe;Cumming, Oliver
大多数关于水、环境卫生和个人卫生的健康影响试验都将儿童腹泻作为主要结局;众所周知，这一指标存在相当大的偏倚，尤其是在非盲试验中使用时。通过多重分子方法检测粪便或粪便废物中的肠道病原体可能比护理人员报告的腹泻具有优势，并且是对护理人员报告的腹泻的补充，因为这些措施是客观的，从感兴趣的暴露到疾病结果的因果途径，并且在高负担国家越来越可行。
Most health impact trials of water, sanitation, and hygiene use caregiver-reported diarrhea in children as the primary outcome; this measure is known to be subject to considerable bias, especially when used in unblinded trials. Detection of enteric pathogens in stool or fecal waste via multiplex molecular methods may offer advantages over-and is complementary to-caregiver-reported diarrhea because these measures are objective, on the causal pathway from exposures of interest to disease outcomes, and increasingly feasible in high-burden countries.