Abnormal parietal cortex activation during working memory in schizophrenia: Verbal phonological coding disturbances versus domain-general executive dysfunction
Abnormal parietal cortex activation during working memory in schizophrenia: Verbal phonological coding disturbances versus domain-general executive dysfunction
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DOI：
10.1176/appi.ajp.164.7.1090
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发表时间：
2007-07-01
影响因子：
17.7
通讯作者：
Csernansky, John G.
中科院分区：
文献类型：
--
作者：
Barch, Deanna M.;Csernansky, John G.
目的：本研究旨在确定精神分裂症患者在工作记忆任务中表现出异常激活的前额叶和顶叶皮质区域是否与以下两种情况相关：1）可能特定于言语任务的语音编码过程（即腹侧前额叶和顶叶皮质）；2）言语和非言语任务所涉及的通用执行过程（即背侧前额叶和顶叶皮质）。
方法：参与者包括57名服用药物的精神分裂症患者和120名健康受试者。在执行言语和非言语的2 - back工作记忆任务期间，使用功能性磁共振成像对所有参与者进行扫描。
结果：在健康受试者中，言语和非言语工作记忆任务均引起相似的双侧背侧前额叶和下顶叶皮质激活，但言语工作记忆任务相较于非言语工作记忆任务引起更大的左侧腹侧前额叶和顶叶皮质激活。精神分裂症患者在言语和非言语工作记忆任务中均表现出双侧背侧额叶和顶叶激活的缺陷。他们在腹侧前额叶和顶叶区域也呈现出言语工作记忆相较于非言语工作记忆活动更强的典型模式，尽管在左侧腹侧前额叶区域言语优势较小。
结论：这些结果支持以下假设：精神分裂症患者的工作记忆缺陷反映的是与工作记忆的中央执行成分相关的大脑区域激活的缺陷，而非特定领域的存储缓冲的缺陷。
Objective: The goal of this study was to determine whether the regions of the prefrontal and parietal cortices showing abnormal activation among individuals with schizophrenia during working memory tasks are associated with either 1) phonological coding processes that may be specific to verbal tasks (i.e., ventral prefrontal and parietal cortices) or 2) domain-general executive processes engaged by verbal and nonverbal tasks (i.e., dorsal prefrontal and parietal cortices).Method: The participants were 57 medicated individuals with schizophrenia and 120 healthy subjects. Functional magnetic resonance imaging was used to scan all participants during performance of verbal and nonverbal 2-back working memory tasks.Results: In the healthy subjects there was similar bilateral dorsal prefrontal and inferior parietal cortex activation for both the verbal and nonverbal working memory tasks, but greater left ventral prefrontal and parietal cortex activation during verbal compared to nonverbal working memory. individuals with schizophrenia showed bilateral deficits in dorsal frontal and parietal activation during both verbal and nonverbal working memory tasks. They also demonstrated the typical pattern of greater activity for verbal, as compared to nonverbal, working memory in ventral prefrontal and parietal regions, although they showed less verbal superiority in a left ventral prefrontal region.Conclusions: These results support the hypothesis that working memory deficits in individuals with schizophrenia reflect deficits in activation of brain regions associated with the central executive components of working memory rather than domain-specific storage buffers.