A brief review of short tandem repeat mutation.
A brief review of short tandem repeat mutation.
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DOI：
10.1016/s1672-0229(07)60009-6
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发表时间：
2007-02
影响因子：
9.5
通讯作者：
Chu, Jia-You
中科院分区：
文献类型：
--
作者：
Fan, Hao;Chu, Jia-You
短串联重复序列（STRs）是短串联重复的DNA序列，涉及1-6 bp的重复单位。由于其多态性和高突变率，STRs在生物学研究中得到了广泛应用。链滑移复制是STRs的主要突变机制，逐步突变模型被认为是主要的突变模型。STR突变率受多种因素影响。此外，一些三核苷酸重复序列与人类神经退行性疾病有关。为了加深我们对这些疾病的认识和扩大STR的应用，有必要详细了解STR的突变过程。在这篇综述中，我们主要关注目前已知的关于STR突变的信息。
Short tandem repeats (STRs) are short tandemly repeated DNA sequences that involve a repetitive unit of 1–6 bp. Because of their polymorphisms and high mutation rates, STRs are widely used in biological research. Strand-slippage replication is the predominant mutation mechanism of STRs, and the stepwise mutation model is regarded as the main mutation model. STR mutation rates can be influenced by many factors. Moreover, some trinucleotide repeats are associated with human neurodegenerative diseases. In order to deepen our knowledge of these diseases and broaden STR application, it is essential to understand the STR mutation process in detail. In this review, we focus on the current known information about STR mutation.