C-FACTOR - A CELL CELL SIGNALING PROTEIN REQUIRED FOR FRUITING BODY MORPHOGENESIS OF M-XANTHUS
C-FACTOR - A CELL CELL SIGNALING PROTEIN REQUIRED FOR FRUITING BODY MORPHOGENESIS OF M-XANTHUS
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DOI：
10.1016/0092-8674(90)90211-v
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发表时间：
1990-04-06
期刊：
影响因子：
64.5
通讯作者：
KAISER, D
中科院分区：
文献类型：
--
作者：
KIM, SK;KAISER, D
During fruiting body development, the product of the csgA gene is necessary for cellular aggregation, for spore differentiation, and for gene expression that is initiated after 6 hr of starvation. From nascent wild-type fruiting bodies we have purified a polypeptide of 17 kd called C-factor, which, at approximately 1 to 2 nM, restores normal development to csgA mutant cells. C-factor activity is not recovered from extracts of unstarved, growing cells or csgA mutant cells. The amino acid sequence from purified C-factor demonstrates that it is the product of the csgA gene. C-factor is active over a narrow range of concentration and has properties of a morphogenetic paracrine signal.
