A Prospective Quasi-Randomized Comparison of Intraoperatively Built Custom-Linked Seeds Versus Loose Seeds for Prostate Brachytherapy
A Prospective Quasi-Randomized Comparison of Intraoperatively Built Custom-Linked Seeds Versus Loose Seeds for Prostate Brachytherapy
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DOI：
10.1016/j.ijrobp.2014.05.009
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发表时间：
2014-09-01
影响因子：
7
通讯作者：
Hayakawa, Kazushige
中科院分区：
文献类型：
--
作者：
Ishiyama, Hiromichi;Satoh, Takefumi;Hayakawa, Kazushige
目的：比较术中自定义连接（IBCL）粒子与松散粒子在前列腺近距离治疗中的剂量学参数、粒子迁移率、手术时间和急性毒性。方法和材料：参与者为140例低或中度前列腺癌患者，采用准随机化方法（按月周分配），前瞻性地分配到IBCL种子组（n = 74）或松散种子组（n = 66）。所有患者均采用交互式计划技术接受前列腺近距离治疗。术后第2天及1个月分别行ct平片和x线平片检查。主要终点是在治疗1个月后，在移植后的计算机断层扫描上检测到5%的剂量与90%前列腺体积的差异。种子迁移被定义为在x线摄影上距离其他种子簇bbb10 1cm的种子位置。进入精囊的种子也被定义为迁移种子。结果：包括主要终点在内的剂量学参数在两组间无显著差异，但IBCL种子组的种子迁移率（0%）显著低于松散种子组（55%）
Purpose: To compare dosimetric parameters, seed migration rates, operation times, and acute toxicities of intraoperatively built custom-linked (IBCL) seeds with those of loose seeds for prostate brachytherapy.Methods and Materials: Participants were 140 patients with low or intermediate prostate cancer prospectively allocated to an IBCL seed group (n = 74) or a loose seed group (n = 66), using quasirandomization (allocated by week of the month). All patients underwent prostate brachytherapy using an interactive plan technique. Computed tomography and plain radiography were performed the next day and 1 month after brachytherapy. The primary endpoint was detection of a 5% difference in dose to 90% of prostate volume on postimplant computed tomography 1 month after treatment. Seed migration was defined as a seed position >1 cm from the cluster of other seeds on radiography. A seed dropped into the seminal vesicle was also defined as a migrated seed.Results: Dosimetric parameters including the primary endpoint did not differ significantly between groups, but seed migration rate was significantly lower in the IBCL seed group (0%) than in the loose seed group (55%; P