Exploring the genetics of rhythmic perception and musical engagement in the Vanderbilt Online Musicality Study.
Exploring the genetics of rhythmic perception and musical engagement in the Vanderbilt Online Musicality Study.
复制标题
在范德比尔特在线音乐性研究中探索节奏感知和音乐参与的遗传学。
DOI：
10.1111/nyas.14964
复制
发表时间：
2023
影响因子：
5.2
通讯作者：
Gordon,ReynaL
中科院分区：
文献类型：
--
作者：
Gustavson,DanielE;Coleman,PeytonL;Wang,Youjia;Nitin,Rachana;Petty,LaurenE;Bush,CatherineT;Mosing,MiriamA;Wesseldijk,LauraW;Ullén,Fredrik;23andMeResearchTeam;Below,JenniferE;Cox,NancyJ;Gordon,ReynaL
揭示音乐能力和参与的遗传基础是探索其与认知，健康和神经发育的广泛关联的基础步骤。先前的研究集中在使用双胞胎和家庭设计，证明音乐表型的中度遗传性。目前的研究使用全基因组复杂性状分析和多基因评分（PGS）方法，利用基因型数据来检查遗传对范德比尔特在线音乐性研究中N = 1792名无关成年人的两种音乐性性状（节奏感知和音乐参与）的影响。Meta分析的遗传率估计值（包括瑞典个体的复制样本）对于节奏感知为31%，对于自我报告的音乐参与为12%。最近一项关于节拍同步能力的研究得出的PGS预测了我们样本中的节奏感知（β= 0.11）和音乐参与度（β= 0.19），这表明自我报告的节拍同步能力背后的遗传影响也会影响个体的节奏辨别能力和他们参与音乐的程度。跨特质分析显示，来自几个非音乐特质（从认知、人格和昼夜节律生理时钟领域）的PGSs对音乐性的个体差异有适度的贡献（β=-0.06至0.07）。这项工作揭示了音乐节奏处理，节拍同步，音乐参与和其他非音乐特征的遗传结构之间的复杂关系。
Uncovering the genetic underpinnings of musical ability and engagement is a foundational step for exploring their wide‐ranging associations with cognition, health, and neurodevelopment. Prior studies have focused on using twin and family designs, demonstrating moderate heritability of musical phenotypes. The current study used genome‐wide complex trait analysis and polygenic score (PGS) approaches utilizing genotype data to examine genetic influences on two musicality traits (rhythmic perception and music engagement) inN= 1792 unrelated adults in the Vanderbilt Online Musicality Study. Meta‐analyzed heritability estimates (including a replication sample of Swedish individuals) were 31% for rhythmic perception and 12% for self‐reported music engagement. A PGS derived from a recent study on beat synchronization ability predicted both rhythmic perception (β= 0.11) and music engagement (β= 0.19) in our sample, suggesting that genetic influences underlying self‐reported beat synchronization ability also influence individuals’ rhythmic discrimination aptitude and the degree to which they engage in music. Cross‐trait analyses revealed a modest contribution of PGSs from several nonmusical traits (from the cognitive, personality, and circadian chronotype domains) to individual differences in musicality (β= −0.06 to 0.07). This work sheds light on the complex relationship between the genetic architecture of musical rhythm processing, beat synchronization, music engagement, and other nonmusical traits.