A computational study of discrete mechanical tissue models
A computational study of discrete mechanical tissue models
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DOI：
10.1088/1478-3975/6/3/036001
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发表时间：
2009-09-01
期刊：
影响因子：
2
通讯作者：
Chapman, S. J.
中科院分区：
文献类型：
--
作者：
Pathmanathan, P.;Cooper, J.;Chapman, S. J.
对离散的“细胞中心”方法进行计算研究，以模拟细胞集合的进化。该研究侧重于组织的机械方面，以便将模型的被动机械反应与细胞生长和细胞分裂等主动效应分离开来。描述了实现这些模型时出现的问题，并进行了一系列数值力学实验。结果表明，以这种方式建模的离散组织在慢压缩下通常表现出弹塑性行为，在慢拉伸下表现为脆性线弹性固体。研究了重叠球体和基于voronoi - tessellla的模型，并确定了不同的细胞-细胞相互作用力规律对组织整体力学性能的影响。这种对应关系允许选择基于细胞的模型中的参数，以与大块组织测量相兼容。
A computational study of discrete 'cell-centre' approaches to modelling the evolution of a collection of cells is undertaken. The study focuses on the mechanical aspects of the tissue, in order to separate the passive mechanical response of the model from active effects such as cell-growth and cell division. Issues which arise when implementing these models are described, and a series of numerical mechanical experiments is performed. It is shown that discrete tissues modelled this way typically exhibit elastic-plastic behaviour under slow compression, and act as a brittle linear elastic solid under slow tension. Both overlapping spheres and Voronoi-tessellation-based models are examined, and the effect of different cell-cell interaction force laws on the bulk mechanical properties of the tissue is determined. This correspondence allows parameters in the cell-based model to be chosen to be compatible with bulk tissue measurements.