Comparing the outcomes between TMLI and non-TMLI conditioning regimens for adult high-risk acute lymphoblastic leukemia patients undergoing allogeneic hematopoietic stem cell transplantation: a single-center experience
Comparing the outcomes between TMLI and non-TMLI conditioning regimens for adult high-risk acute lymphoblastic leukemia patients undergoing allogeneic hematopoietic stem cell transplantation: a single-center experience
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成人高危急性淋巴细胞白血病患者接受异基因造血干细胞移植的 TMLI 和非 TMLI 预处理方案的结果比较：单中心经验
DOI：
10.1080/10428194.2020.1789621
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发表时间：
2020-07
期刊：
影响因子：
--
通讯作者：
Wang HF
中科院分区：
文献类型：
--
作者：
Zhao XY;Lu X;Tang L;Yan H;Chen W;Shi W;Zhong ZD;You Y;Xia LH;Hu Y;Wang HF
摘要本研究旨在回顾性评价成人高危急性淋巴细胞白血病(ALL)患者接受异基因造血干细胞移植(allo-HSCT)后的疗效。70例接受异基因造血干细胞移植的高危ALL成人患者，根据预适应方案分为两组(TMLI组：N = 29例，非TMLI组：N = 41例)。我们注意到在1年内估计的累积复发率(25%比46.5%，p = 0.018)、1年估计总存活率(73.1%比52.6%，p = 0.033)和无病存活率(65.2%比48.2%，p = 0.026)方面有显著的统计学差异，但在移植相关死亡率(12%比13.4%，p = 0.619)方面没有发现显著差异。对于接受allo-HSCT的高危ALL患者来说，含有TMLI的方案是安全和替代的。
Abstract This study aimed to retrospectively evaluate the outcomes of adult patients with high-risk acute lymphoblastic leukemia (ALL) who received allogeneic hematopoietic stem cell transplantation (allo-HSCT) with either total marrow and lymphoid irradiation (TMLI)-containing or non-TMLI conditioning regimen. Seventy adult patients with high-risk ALL who received allo-HSCT were enrolled in this study and divided into two groups based on the conditioning regimen type (TMLI group: n = 29 and non-TMLI group: n = 41). We noted significant statistical differences in the 1-year estimated cumulative incidence of relapse (25% vs. 46.5%, p = 0.018), the 1-year estimated overall survival (73.1% vs. 52.6%, p = 0.033) and disease-free survival (65.2% vs. 48.2%, p = 0.026) but found no considerable difference in transplant-related mortality (12% vs. 13.4%, p = 0.619) between patients in the TMLI and non-TMLI groups. The TMLI-containing regimen is safe and alternative for patients with high-risk ALL undergoing allo-HSCT.
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