Dietary antioxidants and cognitive function in a population-based sample of older persons - The Rotterdam study
Dietary antioxidants and cognitive function in a population-based sample of older persons - The Rotterdam study
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DOI：
10.1093/oxfordjournals.aje.a008922
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发表时间：
1996-08-01
影响因子：
5
通讯作者：
Hofman, A
中科院分区：
文献类型：
--
作者：
Jama, JW;Launer, LJ;Hofman, A
抗氧化剂与动脉粥样硬化、衰老和选择性神经元损伤有关，所有这些都可能最终影响认知功能。在老年人的样本中，作者研究了认知功能与β-胡萝卜素和维生素C和E的饮食摄入量之间的横截面关系。这些数据来自1990年至1993年期间基于人口的鹿特丹研究中5,182名年龄在55-95岁之间的社区参与者。饮食摄入量估计从半定量的食物频率问卷，并分为五个层次的摄入量。认知功能用30分简易精神状态检查（MMSE）测量，并表征为未受损（>25分）或受损（小于或等于25分）。采用Logistic回归分析估计认知功能损害的比值比（OR）和95%可信区间（CI）。在调整了年龄、教育、性别、吸烟、总热量摄入和其他抗氧化剂摄入后，较低的β-胡萝卜素摄入量与认知功能受损相关（
Antioxidants have been implicated in processes related to atherosclerosis, aging, and selective neuronal damage, all of which may ultimately affect cognitive function. In a sample of older persons, the authors examined the cross-sectional relation between cognitive function and dietary intake of beta-carotene and vitamins C and E. The data were derived from 5,182 community participants aged 55-95 years in the population-based Rotterdam Study in the period 1990 to 1993. Dietary intake was estimated from a semi-quantitative food frequency questionnaire and categorized into five levels of intake. Cognitive function was measured with the 30-point Mini-Mental State Examination (MMSE) and characterized as unimpaired (>25 points) or impaired (less than or equal to 25 points). Logistic regression analysis was used to estimate the odds ratio (OR) and 95% confidence interval (CI) for cognitive impairment. After adjustment for age, education, sex, smoking, total caloric intake, and intake of other antioxidants, a lower intake of beta-carotene was associated with impaired cognitive function (