Radiofrequency versus microwave ablation in a hepatic porcine model
Radiofrequency versus microwave ablation in a hepatic porcine model
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DOI：
10.1148/radiol.2361031249
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发表时间：
2005-07-01
期刊：
影响因子：
19.7
通讯作者：
Lee, FT
中科院分区：
文献类型：
--
作者：
Wright, AS;Sampson, LA;Lee, FT
目的：比较微波(MW)和射频(RF)消融在猪肝脏模型中的作用。材料和方法：获得机构动物研究委员会的批准。将19头猪按处死时间分为即刻组、2天组、28天组和28天组。A、B、C组分别接受射频消融和微波消融。D组接受4次微波消融或4次射频消融。消融使用原型微波装置(915兆赫，40W，10分钟)和商用射频系统(150 W，10分钟，3厘米部署)。B、C组于第2天行CT检查，C组于第28天行CT检查。D组进行系列实验室检测。对标本进行连续切片，测量每个标本的短轴直径和长度。结果：微波消融区在0、2、28d均较射频消融组延长(P<；0.05)，但短轴直径与射频消融组比较差异无统计学意义(P>；0.05)。微波消融时局部血管引起3.5%+/-5.3(标准差)的偏转，而射频消融时为26.2%+/-27.9(P<；0.05)。微波消融区和射频消融区在CT或病理评估中无法区分。仅射频消融动物与仅微波消融动物的实验室检测结果相似，但仅射频消融动物在第2天的碱性磷酸酶水平略高(P<；0.02)。结论：微波消融区和射频消融区在病理形态和影像特征上相似。微波烧蚀增加的长度可能是由天线辐射段的长度引起的。微波消融可能较少受到热沉效应的影响，散热效应被认为是射频消融后局部复发的原因。(C)RSNA，2005年。
PURPOSE: To compare microwave (MW) and radiofrequency (RF) ablation in a hepatic porcine model.MATERIALS AND METHODS: Institutional animal research committee approval was obtained. Nineteen pigs were divided into groups based on time of sacrifice (group A, immediate; group B, 2 days; group C, 28 days, group D, 28 days). Groups A, B and C each underwent a combination of RF and MW ablation. Group D underwent either four MW or four RF ablations. Ablation was performed with a prototype MW device (915 Mhz, 40 W, 10 minutes) and a commercial RF system (150 W, 10 minutes, 3-cm deployment). Computed tomography (CT) was performed in groups B and C at 2 days and in group C at 28 days. Group D underwent serial laboratory testing. Specimens were serially sectioned, and short-axis diameter and length of each were measured. The percentage deflection caused by local blood vessels (heat-sink effect) was also measured in group A. Likelihood ratio tests and unpaired t tests were used for statistical analyses as appropriate.RESULTS: MW ablation zones were longer at days 0, 2, and 28 (P < .05), but short-axis diameter was not different from that with RF ablation at any time point (P > .05). Local blood vessels caused 3.5 % +/- 5.3 (standard deviation) deflection at MW ablation compared with 26.2 % +/- 27.9 at RF ablation (P < .05). MW and RF ablation zones were indistinguishable at CT or pathologic evaluation. Laboratory test results were similar between RF ablation-only animals and MW ablation-only animals, with the exception of a slightly higher alkaline phosphatase levels at day 2 in RF ablation-only animals (P < .02).CONCLUSION: MW and RF ablation zones are similar in pathologic appearance and imaging characteristics. Increased length with MW ablation is likely caused by the length of the radiating segment of the antenna. MW ablation may be less affected by the heat-sink effect that is thought to contribute to local recurrence after RF ablation. (c) RSNA, 2005.