The oxidative stress hypothesis of congestive heart failure: radical thoughts.
The oxidative stress hypothesis of congestive heart failure: radical thoughts.
复制标题
充血性心力衰竭的氧化应激假说：激进的想法。
作者：
S. Mak;G. Newton
体外和动物实验中有大量的实验证据表明，充血性心力衰竭（CHF）是一种氧化应激状态。此外，在动物模型中，CHF的发展伴随着心肌抗氧化防御机制的变化以及氧化性心肌损伤的证据。这导致了氧化应激可能是CHF疾病进展的机制的假设。事实上，许多患者服用抗氧化剂补充剂，假设不会造成伤害，并且可能会产生一些临床益处。这篇综述的重点是研究CHF的氧化应激假说，因为它涉及到人类。迄今为止，已经寻找证据证明氧化应激在CHF患者中的作用的人体研究未能为这一假设提供强有力的支持。已经证明氧化应激和CHF之间存在关联的研究很少，并且受到方法学限制的阻碍，这些限制降低了其结论的影响。补充抗氧化剂治疗CHF的随机试验很少，据我们所知，还没有研究令人信服地证明服用抗氧化剂补充剂有任何好处。因此，现有证据不足以支持或否定CHF的氧化应激假说，并且不能推荐使用抗氧化剂作为这种疾病的特异性治疗。
There is extensive experimental evidence from in vitro and animal experiments that congestive heart failure (CHF) is a state of oxidative stress. Moreover, in animal models, the development of CHF is accompanied by changes in the antioxidant defense mechanisms of the myocardium as well as evidence of oxidative myocardial injury. This has led to the hypothesis that oxidative stress may be a mechanism of disease progression in CHF. Indeed, many patients consume antioxidant supplements making the assumption that no harm will result and, possibly, that this therapy will yield some clinical benefits. The focus of this review is to examine the oxidative stress hypothesis of CHF as it pertains to humans. To date, human studies that have sought evidence for a role of oxidative stress in patients with CHF have fallen short of providing strong support for this hypothesis. Studies that have demonstrated an association between oxidant stress and CHF are small and are hindered by methodologic limitations that diminish the impact of their conclusions. Randomized trials of antioxidant supplementation for CHF are scarce, and to our knowledge no study yet convincingly demonstrates any benefit from consuming antioxidant supplements. Therefore, the available evidence is insufficient to support or negate the oxidative stress hypothesis of CHF and the use of antioxidants cannot be recommended as a specific therapy for this condition.
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影响因子：
15.9
作者：
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通讯作者：
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