Raised blood pressure and risk of dementia: our response.
Raised blood pressure and risk of dementia: our response.
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血压升高和痴呆风险：我们的应对措施。
DOI：
10.1093/eurheartj/ehy917
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发表时间：
2019
影响因子：
39.3
通讯作者：
Abell JG
中科院分区：
文献类型：
--
作者：
Abell JG
我们发现，50岁时收缩压（SBP）> 130 mmHg与痴呆风险比（HR）的1.45倍相关。[1]我们估计了当高血压以三种方式定义时的相关性：> _140 mmHg、> _130 mmHg和> _120 mmHg，HR分别为1.39（1.08，1.80）、1.45（1.18，1.79）和1.20（0.97，1.48），分析中调整了社会人口统计学指标。我们的结论是SBP低于常规的> _140 mmHg阈值与痴呆的风险增加有关。我们的研究结果得到了SPRINT记忆和认知降低高血压（SPRINT MIND）试验的初步结果的支持。2在本试验中，与标准治疗组（SBP目标<140 mmHg）相比，强化治疗组（SBP目标<120 mmHg）的轻度认知功能障碍和全因痴呆的综合结局降低了15%。Gregson及其同事3分析了来自临床实践研究数据链（CPRD）的数据，并报告他们的结果不支持我们的发现。我们无法弄清楚他们是如何得出这一结论的，因为他们只分析了与SBP> 140 mmHg相关的HR，而没有分析与130 mmHg和120 mmHg阈值相关的风险。然后，他们使用略有不同的收缩压分类（< 115、115-124、125-134、135-144、145-154和> 155）检查了事件发生率（图1），并且没有对事件发生率的差异进行正式比较，得出的结论是所有类别的发生率都相似。
We found systolic blood pressure (SBP)> _130 mmHg at age 50 to be associated with a 1.45 times great hazard ratio (HR) of dementia. 1 We estimated associations when hypertension was defined in three ways:> _140 mmHg,> _130 mmHg, and> _120 mmHg with HRs of 1.39 (1.08, 1.80), 1.45 (1.18, 1.79), and 1.20 (0.97, 1.48) in analyses adjusted for sociodemographic measures. We concluded that SBP is associated with increased risk of dementia below the conventional> _140 mmHg threshold. Our findings are supported by preliminary results from the SPRINT Memory and Cognition IN Decreased Hypertension (SPRINT MIND) trial. 2 The combined outcome of mild cognitive impairment and all-cause dementia in this trial was reduced by 15% in the intensive treatment group (SBP target< 120 mmHg) compared to the standard treatment group (SBP target< 140 mmHg).Gregson and colleagues 3 analysed data from the Clinical Practice Research Datalink (CPRD) and report their results do not support our findings. We could not work out how they arrived at this conclusion as they analysed only the HR associated with SBP> _ 140 mmHg, not the risk associated with the 130mmHg and 120mmHg thresholds. They then examined event rates (Figure 1) using a somewhat different categorization of SBP (< 115, 115–124, 125–134, 135–144, 145–154, and> 155) and without undertaking a formal comparison of difference in event rates concluded that rates in all categories were similar.
血压升高和患痴呆症的风险。
影响因子：
39.3
作者：
J. Gregson;N. Qizilbash;S. Pocock
通讯作者：
S. Pocock