CDH12 promotes the invasion of salivary adenoid cystic carcinoma
CDH12 promotes the invasion of salivary adenoid cystic carcinoma
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DOI：
10.3892/or.2011.1286
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发表时间：
2011-07-01
期刊：
影响因子：
4.2
通讯作者：
Lu, You-Guang
中科院分区：
文献类型：
--
作者：
Wang, Jin-Feng;She, Lin;Lu, You-Guang
钙粘蛋白存在于几乎所有的生物体中。除了在正常组织结构的形成和维持中的作用外，钙粘蛋白似乎在肿瘤发生、侵袭和转移中癌细胞的细胞-细胞相互作用中起关键作用。本研究旨在探讨CDH 12在涎腺腺样囊性癌（SACC）侵袭和转移中的作用。Real-time PCR结果显示，与具有低转移能力的SACC细胞系ACC-2相比，CDH 12在高转移性SACC细胞系ACC-M中异常表达。CDH 12在有转移和复发的临床标本中的表达显著高于无转移和复发的临床标本（P
Cadherins are found in almost all living organisms. In addition to their role in the formation and maintenance of normal tissue architecture, cadherins seem to play a crucial role in the cell-cell interactions of cancer cells in tumorigenesis, invasion and metastasis. The aim of the present study was to identify the role of CDH12 in the invasion and metastasis of salivary adenoid cystic carcinoma (SACC). Real-time PCR results showed that CDH12 is abnormally expressed in the highly metastatic SACC cell line ACC-M, compared to ACC-2, a SACC cell line with low metastatic ability. CDH12 expression was significantly higher in clinical samples with metastasis and recurrence than in those without metastasis and recurrence (P