Infection with Opisthorchis viverrini and Use of Praziquantel among a Working-age Population in Northeast Thailand
Infection with Opisthorchis viverrini and Use of Praziquantel among a Working-age Population in Northeast Thailand
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DOI：
10.7314/apjcp.2013.14.5.2963
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发表时间：
2013-01-01
影响因子：
--
通讯作者：
Bradshaw, Peter
中科院分区：
文献类型：
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作者：
Saengsawang, Phubet;Promthet, Supannee;Bradshaw, Peter
在泰国东北部，由于食用某些传统淡水鱼菜肴而感染河狸蛇是胆管癌的主要危险因素。在泰国东北部，这种感染是地方性的，这种原发性肝癌的发病率一直是世界上最高的。本文是一项前瞻性研究项目的第二份报告，该项目旨在监测泰国东北部农村社区国家肝吸虫控制规划的影响。684名年龄在20-65岁的村民完成了一份访谈问卷，并使用加藤厚涂片技术进行了感染检测。该问卷旨在探讨OV感染、既往吡喹酮治疗与对该药物的认识和信念之间的关系。采用描述性统计和多元逻辑回归对数据进行分析。OV感染的总体流行率为37.2%，在20-35岁年龄组、大学学历和政府部门工作人员中最高。多达91.8%的人报告说，他们吃了已知会使他们面临感染风险的鱼菜。在多元回归分析中，既往使用吡喹酮和不了解该药是否对再次感染有保护作用是与OV感染相关的唯一因素（ORadj= 2.31, 95% CI= 1.40 ~ 3.79; ORadj= 1.95, 95% CI= 1.24 ~ 3.05）。研究结果讨论了可能不明智的依赖吡喹酮作为控制方案的主要元素。
Infection with Opisthorchis viverrini (OV) due to eating certain traditional freshwater fish dishes is the principal risk factor for cholangiocarcinoma in Northeast Thailand where the infection is endemic and the incidence of this form of primary liver cancer has been the highest in the world. This paper is the second report of a prospective research project to monitor the impacts of a national liver fluke control programme in a rural community of Northeast Thailand. A sample of 684 villagers aged 20-65 years completed an interview questionnaire and were tested for infection using the Kato thick smear technique. The questionnaire was designed for the exploration of associations between OV infection, previous treatment with praziquantel, and knowledge and beliefs about the drug. The data were analysed using descriptive statistics and multiple logistic regression. The overall prevalence of OV infection was 37.2% and was highest in the 20-35 year age group, in those with a university degree and in those employed in the government sector. As many as 91.8% reported eating fish dishes known to place them at risk of infection. In the multiple regression analysis, previous use of praziquantel and lack of knowledge about whether or not the drug has a protective effect against re-infection were the only factors related to OV infection (ORadj= 2.31, 95% CI = 1.40-3.79 and ORadj= 1.95, 95% CI= 1.24-3.05). The findings were discussed in terms of the possibly unwise dependency on praziquantel as a primary element in a control programme.