Relationship between weight loss maintenance and changes in serum leptin levels.
Relationship between weight loss maintenance and changes in serum leptin levels.
复制标题
减肥维持与血清瘦素水平变化之间的关系。
DOI：
10.1055/s-2007-979881
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发表时间：
1996
期刊：
影响因子：
--
通讯作者：
Caro,JF
中科院分区：
文献类型：
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作者：
Wing,RR;Sinha,MK;Considine,RV;Lang,W;Caro,JF
血清瘦素浓度在肥胖的人比在瘦，并降低了初始体重减轻。本研究检查了维持体重减轻对瘦素浓度的影响，并测试了基线或初始体重减轻后的瘦素浓度是否与维持体重减轻的能力有关。52名超重妇女[体重指数（kg/m2）平均为31.3]在4个月减肥计划前后和6个月随访时进行了研究。受试者在4个月的计划中体重减轻了8.1 kg，瘦素浓度从30.1 ng/ml降至20.4 ng/ml。每单位体重指数的初始瘦素水平（r=-0.61，p≤ 0.0001）和0至4个月的体重减轻（r= 0.39，p= 0.004）均与瘦素的初始变化显著相关，共同解释了瘦素变化的60%的方差。在6个月的随访中保持体重减轻的受试者保持瘦素水平的降低;再次，随访期间的体重变化与血清瘦素水平的变化相关（r= 0.41，p= 0.003）。没有证据表明基线瘦素浓度（或瘦素/体重指数）或伴随初始体重减轻的瘦素变化可预测随后的体重恢复。因此，减肥过程中瘦素浓度的变化与体重的变化有关。然而，无论是基线浓度还是瘦素的初始变化都不能预测减肥或维持体重的成功。
Serum leptin concentrations are higher in obese humans than in lean and are decreased by initial weight loss. This study examined the effects of maintenance of weight loss on leptin concentrations and tested whether leptin concentrations at baseline or after initial weight loss are related to the ability to maintain a reduced body weight. Fifty-two overweight women [body mass index (kg/m 2) averaging 31.3] were studied before and after a 4 month weight loss program and at 6 month follow-up. Subjects lost 8.1 kg over the 4 month program, and leptin concentrations decreased from 30.1 to 20.4 ng/ml. Initial leptin level per unit body mass index (r=-0.61, p≤ 0.0001) and weight loss during months 0 to 4 (r= 0.39, p= 0.004) were both significantly associated with initial changes in leptin, and together explained 60% of the variance in change in leptin. Subjects who maintained their weight losses over the 6-month follow-up maintained their reductions in leptin levels; again, weight changes during follow-up were correlated with changes in serum leptin levels (r= 0.41, p= 0.003). There was no evidence that baseline leptin concentration (or leptin/body mass index) or the changes in leptin which accompanied initial weight loss were predictive of subsequent weight regain. Thus, changes in leptin concentration during weight loss track with changes in weight. However, neither baseline concentrations nor initial changes in leptin predict success at weight loss or maintenance.