Normalized electroencephalogram power: a trait with increased risk of dementia.
Normalized electroencephalogram power: a trait with increased risk of dementia.
复制标题
标准化脑电图功率：痴呆风险增加的特征。
DOI：
10.1093/sleep/zsad195
复制
发表时间：
2023
期刊：
影响因子：
5.6
通讯作者：
Stone,KatieL
中科院分区：
文献类型：
--
作者：
Younes,Magdy;Redline,Susan;Peters,Katherine;Yaffe,Kristine;Purcell,Shaun;Djonlagic,Ina;Stone,KatieL
虽然临床痴呆症通常发生在晚年，但大脑的病理过程早在几十年前就开始了。因此，目前的研究重点是在出现临床症状之前识别出痴呆的高危个体。目前，对此类个体的识别往往依赖于神经成像技术和脑脊液分析[b]。基于血液的生物标志物（BBMs）最近被引入临床实践，并在这方面具有很大的前景。由于其广泛可用性，脑电图（EEG）也是一种很有前途的潜在识别风险的工具。虽然轻度认知障碍(MCI)/痴呆患者的脑电图变化已被充分记录在案，但只有一项研究描述了认知正常患者睡眠期间脑电图变化早于确诊的MCI/痴呆患者。该研究发现，患有脑炎和未患脑炎的人在常规睡眠指标上没有差异
Although clinical dementia typically occurs in late life, the pathological process in the brain begins decades earlier [1]. Hence, the current focus of investigation is to identify individuals at high risk of developing dementia before the onset of clinical symptoms [2]. At present, identification of such individuals relies often on neuro-imaging techniques and cerebrospinal fluid analysis [3]. Blood-based biomarkers (BBMs) have recently been introduced in clinical practice and hold great promise in this respect [4]. Because of its wide availability, electroencephalogram (EEG) is also a promising tool for potentially identifying those at risk. Whereas EEG changes in established mild cognitive impairment (MCI)/dementia are well documented [5], only one study described EEG changes during sleep that predate development of adjudicated MCI/dementia in cognitively normal individuals [6]. That study found no difference in conventional sleep metrics between those who did and did not develop