Signaling from Axon Guidance Receptors
Signaling from Axon Guidance Receptors
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DOI：
10.1101/cshperspect.a001941
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发表时间：
2010-05-01
影响因子：
7.2
通讯作者：
Klein, Ruediger
中科院分区：
文献类型：
--
作者：
Bashaw, Greg J.;Klein, Ruediger
确定轴突导向受体如何传递信号以做出精确的寻路决策，对于我们理解神经系统发育至关重要，并且可能为促进损伤或疾病后的轴突再生提供新策略。在无脊椎动物和脊椎动物模型系统中，对作用于四大主要轴突导向信号家族（神经毡蛋白、信号素、肝配蛋白和狭缝蛋白）下游的信号传导机制进行了广泛研究。尽管这些信号传导机制的细节仍然不完整，而且不同的导向受体在调节轴突生长锥的运动性方面似乎存在相当大的差异，但一些共同的主题已经出现。在此，我们综述了关于这些导向信号中每一种的特定受体如何与生长锥细胞骨架的下游调节因子相互作用以控制轴突导向的最新见解。
Determining how axon guidance receptors transmit signals to allow precise pathfinding decisions is fundamental to our understanding of nervous system development and may suggest new strategies to promote axon regeneration after injury or disease. Signaling mechanisms that act downstream of four prominent families of axon guidance cues-netrins, semaphorins, ephrins, and slits-have been extensively studied in both invertebrate and vertebrate model systems. Although details of these signaling mechanisms are still fragmentary and there appears to be considerable diversity in how different guidance receptors regulate the motility of the axonal growth cone, a number of common themes have emerged. Here, we review recent insights into how specific receptors for each of these guidance cues engage downstream regulators of the growth cone cytoskeleton to control axon guidance.