Cycle Thresholds Among Solid Organ Transplant Recipients Testing Positive for SARS-CoV-2.
Cycle Thresholds Among Solid Organ Transplant Recipients Testing Positive for SARS-CoV-2.
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DOI：
10.1097/tp.0000000000003695
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发表时间：
2021-07-01
期刊：
影响因子：
6.2
通讯作者：
Furuya EY
中科院分区：
文献类型：
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作者：
Theodore DA;Greendyke WG;Miko B;Whittier S;Green DA;Shoucri S;Verna EC;Zucker J;Sobieszczyk ME;Aaron JG;Scully BE;Saiman L;Pereira M;Furuya EY
在免疫功能低下的 SARS-CoV-2 患者中，基于传播的预防措施的最佳持续时间尚不清楚。对 2020 年 3 月 13 日至 5 月 15 日期间入院的鼻咽标本 SARS-CoV-2 PCR 结果呈阳性的实体器官移植患者进行回顾性分析。在症状出现后 ≥ 20 天（或无症状个体首次检测呈阳性后）检测到 SARS-CoV-2 PCR 阳性的实体器官移植受者中，有 21% 的循环阈值较低（即病毒载量较高）。这些患者中的大多数没有症状或症状有所改善。实体器官移植受者可能长期承受 SARS-CoV-2 的高病毒负荷。需要进一步的数据来了解周期阈值数据是否有助于制定预防与医疗保健相关的 SARS-CoV-2 传播以及适当停止基于传播的预防措施的策略。
The optimal duration of Transmission-Based Precautions among immunocompromised patients with SARS-CoV-2 is unknown. Retrospective review of patients with solid organ transplant with positive SARS-CoV-2 PCR result from nasopharyngeal specimens admitted to the hospital between 3/13/2020 and 5/15/2020. Twenty-one percent of solid organ transplant recipients with positive SARS-CoV-2 PCR detected ≥ 20 days after symptom onset (or after first positive test among asymptomatic individuals) had a low cycle threshold (i.e. high viral load). The majority of these patients were asymptomatic or symptomatically improved. Solid organ transplant recipients may have prolonged high viral burden of SARS-CoV-2. Further data are needed to understand whether cycle threshold data can help inform strategies for prevention of healthcare-associated transmission of SARS-CoV-2 and for appropriate discontinuation of Transmission-Based Precautions.