Elevated plasma homocysteine level in patients with Parkinson disease - Motor, affective, and cognitive associations
Elevated plasma homocysteine level in patients with Parkinson disease - Motor, affective, and cognitive associations
复制标题
DOI：
10.1001/archneur.61.6.865
复制
发表时间：
2004-06-01
影响因子：
--
通讯作者：
Diaz-Arrastia, R
中科院分区：
文献类型：
--
作者：
O'Suilleabhain, PE;Sung, V;Diaz-Arrastia, R
背景资料：血浆同型半胱氨酸（Hcy）水平升高与血管性和退行性痴呆的风险增加有前瞻性相关性。Hey升高在帕金森病（PD）患者中普遍存在，部分原因是左旋多巴代谢产生Hcy。帕金森病患者高同型半胱氨酸血症的临床意义尚不清楚。目的：确定帕金森病患者的高同型半胱氨酸血症是否与抑郁或认知或身体障碍有关。设计：97例患者的平均（SD）PD持续时间为3.6（1.6）年完成贝克抑郁量表，一组11项认知测试，以及统一帕金森病评定量表的运动和功能部分。在Hey水平正常的患者（n=66）和高同型半胱氨酸血症患者（n=31）之间比较情感、认知和身体测量的标准化评分（Hcy水平>1.89 mg/L [>14 mumol/L]），控制年龄、性别、病程和治疗。受试者与高水平的嘿略老（68比62岁），但有类似的血浆浓度的维生素B-12和叶酸。高同型半胱氨酸血症患者抑郁程度更高（P=.02），认知能力更差（P
Background: An elevated plasma homocysteine (Hcy) level has been prospectively associated with an increased risk of vascular and degenerative dementias. An Hey elevation is prevalent in patients with Parkinson disease (PD) in part because levodopa metabolism produces Hcy. The clinical relevance of an elevated Hey level in patients with PD is unknown.Objective: To determine if hyperhomocysteinemia in patients with PD is associated with depression or with cognitive or physical impairments.Design: Ninety-seven people with a mean (SD) PD duration of 3.6 (1.6) years completed the Beck Depression Inventory, a battery of 11 cognitive tests, and the motor and function components of the Unified Parkinson's Disease Rating Scale. Normalized scores for the affective, cognitive, and physical measures were compared between those with a normal Hey level (n=66) and those with hyperhomocysteinemia (n=31) (Hcy level, >1.89 mg/L [>14 mumol/L]), controlling for age, sex, disease duration, and treatment.Results: Subjects with an elevated Hey level were slightly older (68 vs 62 years), but had similar plasma concentrations of vitamin B-12 and folate. Hyperhomocysteinemic patients were more depressed (P=.02) and had worse cognition (P