Myelodysplastic syndromes: revisiting the role of the bone marrow microenvironment in disease pathogenesis
Myelodysplastic syndromes: revisiting the role of the bone marrow microenvironment in disease pathogenesis
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DOI：
10.1007/s12185-011-1001-x
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发表时间：
2012-01-01
影响因子：
2.1
通讯作者：
Raaijmakers, Marc H. G. P.
中科院分区：
文献类型：
--
作者：
Raaijmakers, Marc H. G. P.
骨髓增生异常综合征是一组异质性疾病，其特征是无效的造血和白血病转化的倾向。其发病机制是复杂的，可能取决于异常造血细胞和它们的微环境之间的相互作用。小生境细胞如何在疾病演变中发挥作用的定义很差，但造血干细胞小生境的描绘和在动物模型中询问其在造血疾病中的作用的能力，近年来进一步加深了我们的见解。这些数据支持这样一种观点，即微环境可以在骨髓增生异常和骨髓增生性疾病的演变中发挥积极作用，从而为探索这些疾病中间充质-造血相互作用的治疗靶向提供了进一步的理论基础。
Myelodysplastic syndromes are a heterogeneous group of diseases characterized by ineffective hematopoiesis and the propensity to leukemic transformation. Their pathogenesis is complex and likely depends on interplay between aberrant hematopoietic cells and their microenvironment. How niche cells play a role in disease evolution is poorly defined, but the delineation of the hematopoietic stem cell niche and the ability to interrogate its role in hematopoietic disease in animal models have furthered our insights in recent years. The data support a view in which the microenvironment can play an active role in the evolution of myelodysplasia and myeloproliferative disorders, thus providing further rationale to explore therapeutic targeting of mesenchymal-hematopoietic interactions in these diseases.