Effects of high oxygen tension on the metabolism of vasoactive hormones in isolated perfused rat lungs.
Effects of high oxygen tension on the metabolism of vasoactive hormones in isolated perfused rat lungs.
复制标题
高氧张力对离体灌注大鼠肺血管活性激素代谢的影响。
DOI：
--
复制
发表时间：
1981
期刊：
影响因子：
--
通讯作者：
Y. S. Bakhle
中科院分区：
文献类型：
--
作者：
H. Toivonen;J. Hartiala;Y. S. Bakhle
The effect of exposure of rats to high concentrations of oxygen (90-95%, normobaric) on the activation of angiotensin I to angiotensin II and on the inactivation of bradykinin, prostaglandin E2 (PGE2) and 5-hydroxytryptamine (serotonin) in the pulmonary circulation of isolated perfused rat lungs was investigated. After 36 h exposure, PGE2 survival in the pulmonary circulation increased and reached 3 times the control value after 48 h exposure. A decrease in the conversion of angiotensin I to angiotensin II was seen after 48 h exposure. No decrease in the inactivation of 5-hydroxytryptamine was seen until after 60 h exposure. At this time bradykinin inactivation was also decreased. The decrease in metabolism of angiotensin I and PGE2 following 48 h exposure to oxygen was reversed by a subsequent exposure to room air for 12 h. In these experiments, therefore, the earliest sign of oxygen toxicity was a decrease in PGE2 metabolism, a reaction associated with cells other than endothelial cells.
