EFFECT OF MUSCLE DENERVATION ON GROWTH OF TRANSPLANTED TUMOR IN MICE
EFFECT OF MUSCLE DENERVATION ON GROWTH OF TRANSPLANTED TUMOR IN MICE
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DOI：
10.1073/pnas.67.3.1521
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发表时间：
1970-01-01
影响因子：
11.1
通讯作者：
WILDMAN, E
中科院分区：
文献类型：
--
作者：
BATKIN, S;PIETTE, LH;WILDMAN, E
在20%的小鼠腓肠肌去神经支配后，观察到移植的圆细胞神经母细胞瘤在小鼠腓肠肌中生长的暂时阻滞。这些去神经动物的肿瘤细胞显示出结构改变和功能退化。当这些改变的细胞与相关的去神经肌肉组织混合时，向其添加新鲜肿瘤，在神经支配的肌肉中随后移植时产生更高百分比的阻滞。
A temporary retardation of transplanted Round Cell Neuroblastoma growth in the gastrocnemius muscle of mice was observed in 20% of the animals after denervation of the muscle. The tumor cells in these denervated animals showed structural alterations and deterioration in function. These altered cells when mixed with associated denervated muscle tissue, to which was added fresh tumor, produced a higher percentage of retardation upon subsequent transplants in innervated muscle.