Noninvasive Monitoring of Placental Oxygenation by Near-Infrared Spectroscopy
Noninvasive Monitoring of Placental Oxygenation by Near-Infrared Spectroscopy
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DOI：
10.1055/s-0030-1247600
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发表时间：
2010-06-01
影响因子：
2
通讯作者：
Kanayama, Naohiro
中科院分区：
文献类型：
--
作者：
Kakogawa, Jun;Sumimoto, Kazuhiro;Kanayama, Naohiro
我们评估了近红外光谱定量测量胎盘氧合在无创性评估孕妇子宫胎盘功能中的临床应用价值。我们进行了一项前瞻性、观察性的临床研究。入选无并发症妇女(n=15)、先兆早产妇女(n=6)和胎儿宫内发育受限妇女(n=6)。用Niro-300(滨松光子仪，日本滨松市)测量胎盘组织氧合指数(TOI)。平均TOI在无并发症组为72.3+/-5.3%，在TPD组为72.9+/-5.6%，在IUGR组为78.7+/-3.0%。IUGR孕妇的平均TOI显著高于其他两组(p<；0.05)。在IUGR组，尽管入院测量时的胎龄小于住院时的胎龄(p<；0.05)，但TOI与测量时的胎龄没有差异。孕妇TOI较高提示胎盘功能下降。近红外光谱定量监测TOI具有很高的临床应用潜力，特别是在产前管理方面。
We evaluated the clinical usefulness of near-infrared spectroscopic quantitative measurement of placental oxygenation for the noninvasive estimation of uteroplacental function in pregnant women. We performed a prospective, observational clinical study. Women without complications (n = 15), women with threatened preterm delivery (TPD; n = 6), and women with intrauterine fetal growth restriction (IUGR; n = 6) were enrolled. Measurements of placental tissue oxygenation index (TOI) using the NIRO-300 (Hamamatsu Photonics, Hamamatsu City, Japan) were recorded. Mean TOI was 72.3 +/- 5.3% in women without complications, 72.9 +/- 5.6% in pregnant women with TPD, and 78.7 +/- 3.0% in pregnant women with IUGR. Mean TOI in pregnant women with IUGR was significantly higher than that of the other two groups (p < 0.05). In the IUGR group, although gestational age at measurement on admission was less than that made during hospitalization (p < 0.05), there were no differences in the TOI in relation to gestational age at measurement. Higher TOIs in pregnant women suggest decreased placental function. Monitoring the TOI by near-infrared spectroscopic quantitative measurement may have a high potential for clinical application, particularly in prenatal management.