Detection of Parent-of-Origin Effects for Quantitative Traits in Complete and Incomplete Nuclear Families With Multiple Children
Detection of Parent-of-Origin Effects for Quantitative Traits in Complete and Incomplete Nuclear Families With Multiple Children
复制标题
检测多子女完整和不完整核心家庭数量性状的父母效应
DOI：
10.1093/aje/kwr056
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发表时间：
2011-07-15
影响因子：
5
通讯作者：
Fung, Wing Kam
中科院分区：
文献类型：
--
作者：
He, Feng;Zhou, Ji-Yuan;Fung, Wing Kam
对于双等位基因遗传标记基因座，父母不对称性测试（PAT）等测试对于检测起源父母效应是简单而强大的。然而，这些方法仅适用于质量性状，因此目前不适合数量性状。本文提出了一种新的PAT型父母源效应检验方法，它适用于父母双方都有任意数量子女的数量性状的家庭，记为Q-PAT（c），其中c为常数。作者进一步开发了Q-1-PAT（c），用于检测每个家庭中只有一个父母的信息时的起源父母效应。作者建议用Q-C-PAT（c）检验来合并双亲基因型数据的家系和只有一个双亲基因型数据的家系。模拟研究表明，所提出的测试控制的经验I型错误率，以及在零假设下，没有父母的原产地的影响。功效比较也表明，所提出的方法是更强大的比现有的似然比检验。虽然在研究数量性状的方法中通常假设正态性，但本文提出的检验并没有对数量性状的分布做任何假设。
For a diallelic genetic marker locus, tests like the parental-asymmetry test (PAT) are simple and powerful for detecting parent-of-origin effects. However, these approaches are applicable only to qualitative traits and thus are currently not suitable for quantitative traits. In this paper, the authors propose a novel class of PAT-type parent-of-origin effects tests for quantitative traits in families with both parents and an arbitrary number of children, which is denoted by Q-PAT(c) for some constant c. The authors further develop Q-1-PAT(c) for detection of parent-of-origin effects when information is available on only 1 parent in each family. The authors suggest the Q-C-PAT(c) test for combining families with data on both parental genotypes and families with data on only 1 parental genotype. Simulation studies show that the proposed tests control the empirical type I error rates well under the null hypothesis of no parent-of-origin effects. Power comparison also demonstrates that the proposed methods are more powerful than the existing likelihood ratio test. Although normality is commonly assumed in methods for studying quantitative traits, the tests proposed in this paper do not make any assumption about the distribution of the quantitative trait.