The importance of antimicrobial resistance in medical mycology.
The importance of antimicrobial resistance in medical mycology.
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DOI：
10.1038/s41467-022-32249-5
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发表时间：
2022-09-12
影响因子：
16.6
通讯作者：
中科院分区：
文献类型：
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作者：
在SARS-CoV-2大流行之前，抗生素耐药性被列为全球卫生保健的主要优先事项。包括奥尼尔报告在内的一些分析预测，到2050年，耐药细菌感染导致的死亡人数可能会超过癌症死亡人数。虽然公众对真菌感染的认识仍然很模糊，但每年可归因的死亡总数与疟疾、结核病或艾滋病毒造成的全球死亡率相当，甚至超过了这些死亡率。真菌感染的影响因抗真菌药物耐药菌株和物种的稳步上升而加剧，这反映了抗真菌药物在预防和治疗中的广泛使用，并且在曲霉属中的唑类耐药的情况下，与抗真菌药物的广泛农业使用有关。这篇综述基于医学研究理事会和埃克塞特大学主办的研讨会，阐明了抗真菌药物耐药性的问题，并提出了如何减轻这种日益增长的威胁。真菌感染对人类健康的影响因抗真菌药物耐药性的上升而加剧。在这篇综述中，作者概述了抗真菌药物耐药性的问题，并建议如何减轻这种日益增长的威胁。
Prior to the SARS-CoV-2 pandemic, antibiotic resistance was listed as the major global health care priority. Some analyses, including the O’Neill report, have predicted that deaths due to drug-resistant bacterial infections may eclipse the total number of cancer deaths by 2050. Although fungal infections remain in the shadow of public awareness, total attributable annual deaths are similar to, or exceeds, global mortalities due to malaria, tuberculosis or HIV. The impact of fungal infections has been exacerbated by the steady rise of antifungal drug resistant strains and species which reflects the widespread use of antifungals for prophylaxis and therapy, and in the case of azole resistance in Aspergillus, has been linked to the widespread agricultural use of antifungals. This review, based on a workshop hosted by the Medical Research Council and the University of Exeter, illuminates the problem of antifungal resistance and suggests how this growing threat might be mitigated. The impact of fungal infections on human health has been exacerbated by the rise of antifungal drug resistance. In this Review, the authors outline the problem of antifungal resistance and suggest how this growing threat might be mitigated.
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DOI：
10.3390/antibiotics9120877
发表时间：
2020-12-08
期刊：
Antibiotics (Basel, Switzerland)
影响因子：
--
作者：
Arastehfar A;Gabaldón T;Garcia-Rubio R;Jenks JD;Hoenigl M;Salzer HJF;Ilkit M;Lass-Flörl C;Perlin DS
通讯作者：
Perlin DS
影响因子：
13.2
作者：
Buil JB;Oliver JD;Law D;Baltussen T;Zoll J;Hokken MWJ;Tehupeiory-Kooreman M;Melchers WJG;Birch M;Verweij PE
通讯作者：
Verweij PE
影响因子：
5.2
作者：
De Cesare, Giuseppe Buda;Hafez, Ahmed;Stead, David;Llorens, Carlos;Munro, Carol A.
通讯作者：
Munro, Carol A.
影响因子：
6.4
作者：
Arendrup, Maiken Cavling;Patterson, Thomas F.
通讯作者：
Patterson, Thomas F.
影响因子：
6.7
作者：
Burks C;Darby A;Gómez Londoño L;Momany M;Brewer MT
通讯作者：
Brewer MT