Quality, labeling accuracy, and cost comparison of purified soy isoflavonoid products.
Quality, labeling accuracy, and cost comparison of purified soy isoflavonoid products.
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纯化大豆异黄酮产品的质量、标签准确性和成本比较。
DOI：
10.1089/acm.2004.10.1053
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发表时间：
2004
期刊：
影响因子：
--
通讯作者：
Hu,Ming
中科院分区：
文献类型：
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作者：
Chua,Richard;Anderson,Kitty;Chen,Jun;Hu,Ming
目的：为了评估标签的准确性和产品的均匀性，可在东部华盛顿州地区的13个产品，并进行成本比较的基础上，以毫克为单位的11个products.Design：十三（13）的大豆产品（7片和6胶囊配方）随机获得的健康食品，杂货店，药店在东部华盛顿州。使用75%乙醇提取同一产品的四个不同样品。使用梯度高效液相色谱（HPLC）方法分析每个样品的异黄酮含量。使用纯大豆异黄酮标准品定量染料木黄酮、大豆苷元和黄豆黄素及其各自糖苷的含量。然后将每个购买产品的总重量除以其购买价格，以基于50 mg/d的剂量进行产品之间的成本比较。然而，产品的组成存在显著差异。13种产品中只有4种含有至少90%的标签上声称的维生素A含量，2种产品在HPLC色谱图中含有超过40%的杂质。同一厂家生产的2种相同产品的总黄酮含量无差异，但主要成分的百分比随时间发生了显著变化。以50 mg/d剂量计算，30天的供应成本在3.20美元至65.88美元之间。结论：受试产品之间缺乏一致性，大多数（67%）产品的含量低于标示量的90%。产品之间的组成以及同一产品的组成随时间推移存在显著差异。消费者不能相信广告产品标签准确地代表了产品的内容，也不能相信产品定价是广告内容的反映。
Objectives:To evaluate the labeling accuracy and product uniformity of available soy isoflavone products in the eastern Washington State region for 13 products and to perform a cost comparison based on the isoflavone content in milligrams for 11 products.Design:Thirteen (13) isoflavone products (7 tablet and 6 capsule formulations) were randomly obtained from health food, grocery, and pharmacy outlets in eastern Washington State. Four different samples of the same product were extracted using 75% ethanol. Each sample was analyzed for isoflavone content using a gradient high-performance liquid chromatography (HPLC) method. Pure isoflavonoid standards were used to quantify the content of genistein, daidzein, and glycitein and their respective glycosides. The amount of total isoflavonoids per purchased product was then divided into its purchase price in order to make cost comparisons between the products based on a 50 mg/d dose.Results:The weight variation within each product was generally small (<4%). However, there was significant variability in the composition of the products. Only 4 of the 13 products contained at least 90% of the isoflavone content claimed on the label and 2 of products contained impurities in the HPLC chromatogram that exceeded 40%. There was no difference in the total isoflavonoid contents of the 2 identical products made by the same manufacturer, but the percentages of the main components had changed significantly over time. Based on a 50-mg isoflavone per day dose, the cost of a 30-day supply ranged from $3.20 to $65.88.Conclusion:There is a lack of uniformity among the products tested and the majority (67%) of the products contained less than 90% of labeled amounts. There is significant variability in the compositions between the products and in the composition of the same product over time. Consumers cannot trust isoflavonoid product labels to represent the product’s content accurately or that product pricing is a reflection of isoflavone content.