Altered DNA methylation in kidney disease: useful markers and therapeutic targets.
Altered DNA methylation in kidney disease: useful markers and therapeutic targets.
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DOI：
10.1007/s10157-022-02181-5
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发表时间：
2022-04
影响因子：
2.3
通讯作者：
Hayashi K
中科院分区：
文献类型：
--
作者：
Hayashi K
最近的研究表明表观基因组改变与生活方式相关疾病之间存在关联。表观遗传调控促进生物可塑性以应对环境变化，这种可塑性可能会导致“记忆效应”、短暂治疗的持续效应或生活方式相关疾病过程中的损害。我们研究了肾脏完整性所需的几个基因的表观遗传变化的重要性，包括足细胞中的去氧肾上腺素基因，以及持续的抗蛋白尿作用，重点关注转录因子 Krüppel 样因子 4 (KLF4)。我们进一步报道了 DNA 修复因子赖氨酸乙酰基转移酶 5 (KAT5) 与 KLF4 协同作用，通过加速 DNA 损伤和表观遗传改变，在高血糖状态引起的足细胞损伤中的作用。相比之下，近端肾小管细胞中的 KAT5 通过表观遗传机制的肾小球滤过调节以及促进 DNA 修复来预防急性肾损伤，表明 DNA 修复因子的细胞类型特异性作用和作用。这篇综述总结了肾脏疾病的表观遗传改变，特别是 DNA 甲基化，及其作为标记物和潜在治疗靶点的用途。关注与表观遗传变化相关的转录因子或 DNA 损伤修复因子可能是有意义的，因为它们具有细胞特异性的表达或作用。我们相信，更好地了解肾脏的表观遗传改变将有助于制定慢性肾脏病（CKD）治疗的新策略。
Recent studies have demonstrated the association of altered epigenomes with lifestyle-related diseases. Epigenetic regulation promotes biological plasticity in response to environmental changes, and such plasticity may cause a ‘memory effect’, a sustained effect of transient treatment or an insult in the course of lifestyle-related diseases. We investigated the significance of epigenetic changes in several genes required for renal integrity, including the nephrin gene in podocytes, and the sustained anti-proteinuric effect, focusing on the transcription factor Krüppel-like factor 4 (KLF4). We further reported the role of the DNA repair factor lysine-acetyl transferase 5 (KAT5), which acts coordinately with KLF4, in podocyte injury caused by a hyperglycemic state through the acceleration of DNA damage and epigenetic alteration. In contrast, KAT5 in proximal tubular cells prevents acute kidney injury via glomerular filtration regulation by an epigenetic mechanism as well as promotion of DNA repair, indicating the cell type-specific action and roles of DNA repair factors. This review summarizes epigenetic alterations in kidney diseases, especially DNA methylation, and their utility as markers and potential therapeutic targets. Focusing on transcription factors or DNA damage repair factors associated with epigenetic changes may be meaningful due to their cell-specific expression or action. We believe that a better understanding of epigenetic alterations in the kidney will lead to the development of a novel strategy for chronic kidney disease (CKD) treatment.
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影响因子：
8.3
作者：
Ishiguro, Kimiko;Hayashi, Kaori;Itoh, Hiroshi
通讯作者：
Itoh, Hiroshi
影响因子：
5.8
作者：
Hishikawa A;Hayashi K;Kubo A;Miyashita K;Hashiguchi A;Kinouchi K;Yoshimoto N;Nakamichi R;Akashio R;Sugita E;Azegami T;Monkawa T;Suematsu M;Itoh H
通讯作者：
Itoh H
影响因子：
16.6
作者：
Chu AY;Tin A;Schlosser P;Ko YA;Qiu C;Yao C;Joehanes R;Grams ME;Liang L;Gluck CA;Liu C;Coresh J;Hwang SJ;Levy D;Boerwinkle E;Pankow JS;Yang Q;Fornage M;Fox CS;Susztak K;Köttgen A
通讯作者：
Köttgen A
Dnmt1 和 Dnmt3a 维持 DNA 甲基化并调节成人前脑神经元的突触功能
影响因子：
25
作者：
Feng, Jian;Zhou, Yu;Campbell, Susan L.;Le, Thuc;Li, En;Sweatt, J. David;Silva, Alcino J.;Fan, Guoping
通讯作者：
Fan, Guoping
影响因子：
158.5
作者：
Holman, Rury R.;Paul, Sanjoy K.;Neil, H. Andrew W.
通讯作者：
Neil, H. Andrew W.