Synthesis, characterization, electrochemical studies and antitumor activity of some new chalcone analogues containing ferrocenyl pyrazole moiety
Synthesis, characterization, electrochemical studies and antitumor activity of some new chalcone analogues containing ferrocenyl pyrazole moiety
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DOI：
10.1016/j.bioorg.2009.09.003
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发表时间：
2010-02-01
影响因子：
5.1
通讯作者：
Joksovic, Milan D.
中科院分区：
文献类型：
--
作者：
Ratkovic, Zoran;Juranic, Zorica D.;Joksovic, Milan D.
合成了一系列新的含二茂铁基吡唑结构的接枝型不饱和共轭酮，并用红外光谱和核磁共振谱对其结构进行了表征。通过循环伏安法进行主题化合物的电化学表征。采用MIT法研究了所合成化合物对宫颈癌HeLa细胞、黑色素瘤Fem-x细胞和髓性白血病K562细胞的体外细胞毒活性。与作为参比化合物的顺铂相比，含有3-吡啶基的衍生物II在1 β 562细胞系的细胞生长抑制中表现出更好的细胞毒活性。(C)2009爱思唯尔公司All rights reserved.
A series of new raft-unsaturated conjugated ketones containing ferrocenyl pyrazole unit were synthesized and fully characterized by IR and NMR spectroscopy. Electrochemical characterization of subject compounds was performed by means of cyclic voltametry. The in vitro cytotoxic activity of all the synthesized compounds was studied against cervix adenocarcinoma HeLa, melanoma Fem-x and myelogenous leukemia K562 cell lines by the MIT method. Derivative II containing 3-pyridyl moiety exhibited a better cytotoxic activity in the cell growth inhibition of 1(562 cell lines in comparison with cisplatin as a reference compound. (C) 2009 Elsevier Inc. All rights reserved.