MicroRNA-29a/b/c targets iNOS and is involved in protective remote ischemic preconditioning in an ischemia-reperfusion rat model of non-alcoholic fatty liver disease
MicroRNA-29a/b/c targets iNOS and is involved in protective remote ischemic preconditioning in an ischemia-reperfusion rat model of non-alcoholic fatty liver disease
复制标题
MicroRNA-29a/b/c 以 iNOS 为靶点，参与非酒精性脂肪肝病缺血再灌注大鼠模型的保护性远程缺血预处理
DOI：
10.3892/ol.2017.5623
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发表时间：
2017-03-01
期刊：
影响因子：
2.9
通讯作者：
An, Yong
中科院分区：
文献类型：
--
作者：
Duan, Yun-Fei;Sun, Dong-Lin;An, Yong
远程缺血预处理（RIPC）保护免受缺血和再灌注（IR）引起的损伤;然而，RIPC在非酒精性霍利奇脂肪性肝病（NAFLD）肝脏IR损伤中的作用尚不清楚。在这项研究中，NAFLD大鼠模型被用于一系列不同的外科手术和分子实验。IR组和RIPC+IR组的大鼠表现出比NAFLD对照大鼠（其中在正中切口剖腹术后刺激肝脏）更严重的损伤。血清谷丙转氨酶和谷草转氨酶水平测定显示，RIPC+IR组的肝脏状况优于IR组。此外，RIPC+IR组的丙氨酸转氨酶和天冬氨酸转氨酶水平低于IR组（P
Remote ischemic preconditioning (RIPC) protects against the injury that is incurred by ischemia and reperfusion (IR); however, the role of RIPC in liver IR injury in non-alco-holic fatty liver disease (NAFLD) remains unclear. In this study, a NAFLD rat model was utilized in a series of different surgical procedures and molecular experiments. Rats of the IR group and the RIPC+IR group exhibited more severe injury than NAFLD control rats (in which the liver was prodded following a median-incision laparotomy). The liver condition, measured by serum alanine transaminase and aspartate transaminase levels, of the RIPC+IR group was better than that of the IR group. In addition, alanine transaminase and aspartate transaminase levels were lower in the RIPC+IR group compared with the IR group (P