Salt Taste Sensitivity and Heart Failure Outcomes Following Heart Failure Hospitalization.
Salt Taste Sensitivity and Heart Failure Outcomes Following Heart Failure Hospitalization.
复制标题
心力衰竭住院后的盐味敏感性和心力衰竭结果。
DOI：
10.1016/j.amjcard.2020.04.008
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发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Hummel,ScottL
中科院分区：
文献类型：
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作者：
Cohen,LauraP;Wessler,JeffreyD;Maurer,MathewS;Hummel,ScottL
心力衰竭 (HF) 住院后盐味敏感性可能会发生变化，但盐味敏感性变化与心力衰竭症状、生物标志物和结果之间的关系尚不清楚。我们使用经过验证的护理点盐味测试评估了心衰住院后 12 周内的盐味敏感性。受试者被分为两组：盐味敏感性增加或不增加。使用 2 个样本测试和非正态分布参数的对数转换测试来比较 HF 生物标志物和结果。与盐味敏感性未增加的受试者相比，12 周内盐味敏感性增加的受试者的基线特征通常没有差异。 12 周住院天数分别为 60 天和 121 天，盐味敏感度增加组和未增加组住院患者的平均住院天数分别为 5.45 [3.88] 和 11.00 [6.74] (p=0.03)。总之，在心衰住院后 12 周内，部分受试者（但并非所有受试者）的盐味敏感性发生了变化。在此期间盐味敏感性增加的受试者重新住院的天数较少。盐味敏感性的改善可能代表心衰出院后患者的一个新的预后因素。
Salt taste sensitivity can change after heart failure (HF) hospitalization, however the relation between changes in salt taste sensitivity with HF symptoms, biomarkers, and outcomes is unknown. We assessed salt taste sensitivity over 12 weeks following HF hospitalization using a validated, point-of-care salt taste test. Subjects were divided into 2 groups: increase or no increase in salt taste sensitivity. HF biomarkers and outcomes were compared using 2-samplettests and log-transformedttests for non-normally distributed parameters. Baseline characteristics generally did not differ for subjects with an increase in salt taste sensitivity over 12 weeks compared with those without an increase in salt taste sensitivity. The total number of 12-week hospital days was 60 versus 121 days, with an average number of hospital days of 5.45 [3.88] versus 11.00 [6.74] (p = 0.03) among those hospitalized in the groups with an increase versus no increase in salt taste sensitivity, respectively. In conclusion, changes in salt taste sensitivity occurred in some but not all subjects in a 12-week period following HF hospitalization. Subjects with increased salt taste sensitivity over this time period were rehospitalized for fewer days. Improved salt taste sensitivity may represent a novel prognostic factor in postdischarge patients with HF.