Clinical and genetic risk factors of herpes zoster in patients with systemic lupus erythematosus
Clinical and genetic risk factors of herpes zoster in patients with systemic lupus erythematosus
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DOI：
10.1007/s00296-003-0403-3
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发表时间：
2005-03-01
影响因子：
4
通讯作者：
Yoo, DH
中科院分区：
文献类型：
--
作者：
Kang, TY;Lee, HS;Yoo, DH
目的：本研究的目的是确定影响系统性红斑狼疮（SLE）患者带状疱疹发生的临床和遗传危险因素。方法：符合美国风湿病学会标准的 303 名 SLE 患者纳入本研究。当发现典型的聚集性水泡时，即可诊断出带状疱疹。回顾性审查医疗记录以收集临床信息。对于 Fc γ 受体 IIa (Fc γ RIIa) 和 Fc γ RIIIa 基因分型，使用等位基因特异性引物进行聚合酶链反应 (PCR)。 PCR序列特异性寡核苷酸探针方法用于人类HLA-DRB1基因分型。结果：303例SLE患者中发生带状疱疹42例（13.9%）。 SLE 患者带状疱疹的发病率为每年 32.5/1,000 例。带状疱疹患者狼疮性肾炎发生率较高（P=0.018），抗Sm抗体阳性率较高（P=0.019）。然而，FcγRIIa和FcγRIIIa多态性和HLA-DRB1基因型并不影响带状疱疹的发生。结论：患有狼疮性肾炎或抗Sm抗体的系统性红斑狼疮患者发生带状疱疹的风险较高。 Fc gamma RIIa (H/R131)、Fc gamma RIIIa (F/V176) 和 HLA-DRB1 基因多态性并不影响这些患者带状疱疹的发生。
Objective: The aim of this study was to determine the clinical and genetic risk factors that influence herpes zoster occurrence in patients with systemic lupus erythematosus (SLE). Methods: Three hundred three SLE patients meeting the American College of Rheumatology criteria were enrolled in this study. Herpes zoster was diagnosed when classic grouped vesicles were noted. Medical records were reviewed retrospectively to collect clinical information. For Fc gamma receptor IIa (Fc gamma RIIa) and Fc gamma RIIIa genotyping, polymerase chain reaction (PCR) using allele-specific primers was performed. The PCR sequence-specific oligonucleotide probe method was utilized in human HLA-DRB1 genotyping. Results: Forty-two cases (13.9%) of zoster occurred among 303 SLE patients. The incidence of zoster in patients with SLE was 32.5/1,000 patients per year. Patients who developed zoster had higher rates of lupus nephritis (P=0.018) and positive anti-Sm antibody (P=0.019). However, Fc gamma RIIa and Fc gamma RIIIa polymorphism and the HLA-DRB1 genotype did not influence herpes zoster occurrence. Conclusion: Systemic lupus erythematosus patients with lupus nephritis or anti-Sm antibody are at higher risk of herpes zoster. Fc gamma RIIa (H/R131), Fc gamma RIIIa (F/V176), and HLA-DRB1 genetic polymorphisms did not influence the occurrence of herpes zoster in these patients.