Interrelationships between hormones, behavior, and affect during adolescence - Complex relationships exist between reproductive hormones, stress-related hormones, and the activity of neural systems that regulate behavioral affect - Comments on Part III
Interrelationships between hormones, behavior, and affect during adolescence - Complex relationships exist between reproductive hormones, stress-related hormones, and the activity of neural systems that regulate behavioral affect - Comments on Part III
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DOI：
10.1196/annals.1308.015
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发表时间：
2004-01-01
期刊：
影响因子：
--
通讯作者：
Cameron, JL
中科院分区：
文献类型：
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作者：
Cameron, JL
青春期是生命中的一个变化时期，包括与青春期发育有关的生理变化，社会地位的变化和个人面临的社会压力，以及行为影响调节的变化。生殖轴活动、调节压力的神经系统、应激反应产生的激素以及控制行为影响调节的神经系统之间的相互作用是复杂而多方面的。虽然我们对这些相互作用的理解仍然是初步的，但我们确实知道压力可以抑制生殖轴的活动，生殖激素可以调节控制身体对压力反应的神经系统的活动，抑郁症患者的生殖功能和压力反应都可以改变，并且调节行为影响的一些关键神经系统的功能（即，肾上腺素能、去甲肾上腺素能、多巴胺能系统）受性腺类固醇激素和肾上腺类固醇激素调节。本摘要回顾了本节中讨论的关于青春期激素、行为和情感之间相互关系的核心相互作用，并确定了需要进一步调查的关键主题，以了解青春期生殖功能的变化与生活压力的增加相互作用，在调节青春期行为情感调节中发挥的作用。
Adolescence is a period in life marked by change, encompassing physiological changes associated with pubertal development, changes in social status and the social stresses that an individual faces, and changes in behavioral affect regulation. The interactions between activity in the reproductive axis, the neural systems that regulate stress, hormones produced in response to stress, and neural systems governing behavioral affect regulation are complex and multifaceted. Although our understanding of these interactions remains rudimentary, we do know that stress can suppress activity of the reproductive axis, that reproductive hormones can modulate the activity of neural systems that govern the body's responses to stress, that both reproductive function and stress responsiveness can be altered in depressed individuals, and that the function of some of the key neural systems regulating behavioral affect (i.e., serotonergic, noradrenergic, dopaminergic systems) are modulated by both gonadal steroid hormones and adrenal steroid hormones. This summary reviews the central interactions discussed in this session on the interrelationships between hormones, behavior, and affect during adolescence and identifies key topics that require further investigation in order to understand the role that pubertal changes in reproductive function, interacting with increased exposure to life stresses, play in modulating behavioral affect regulation during the adolescent period.