INDUCTION OF SYNAPTIC POTENTIATION IN HIPPOCAMPUS BY PATTERNED STIMULATION INVOLVES 2 EVENTS
INDUCTION OF SYNAPTIC POTENTIATION IN HIPPOCAMPUS BY PATTERNED STIMULATION INVOLVES 2 EVENTS
复制标题
DOI：
10.1126/science.3704635
复制
发表时间：
1986-05-23
期刊：
影响因子：
56.9
通讯作者：
LYNCH, G
中科院分区：
文献类型：
--
作者：
LARSON, J;LYNCH, G
当突触以200毫秒而不是2秒的间隔发生时，电刺激海马体中的轴突时，会产生类似于体内活动模式的短高频突触后反应的稳定增强。200毫秒后，当一个脉冲作用于一个输入端，而第二个脉冲作用于同一个靶神经元的不同输入时，只有被第二个脉冲激活的突触显示出稳定的增强。即使当两种输入支配突触后细胞的完全不同的区域时，也能观察到这种效应；但当两种输入同时受到刺激或第二次爆发延迟2秒时，这种影响就不会发生。细胞内记录显示，第一次爆发延长了200毫秒后诱发的兴奋性突触后电位的衰减期。这些结果表明，单次轴突刺激产生了一种短暂的、空间弥散的启动效应，延长了对随后爆发的反应，这些改变的反应触发了空间受限的突触修改。启动效应的时间参数与学习期间支配海马脑电的theta节律的相似性表明，这种启动可能参与了行为诱导的突触可塑性。
Electrical stimulation of axons in the hippocampus with short high-frequency bursts that resemble in vivo activity patterns produces stable potentiation of postsynaptic responses when the bursts occur at intervals of 200 milliseconds but not 2 seconds. When a burst was applied to one input and a second burst applied to a different input to the same target neuron 200 milliseconds later, only the synapses activated by the second burst showed stable potentiation. This effect was observed even when the two inputs innervated compeltely different regions of the postsynaptic cells; but did not occur when the inputs were stimulated simultaneously or when the second burst was delayed by 2 seconds. Intracellular recordings indicated that the first burst extended the decay phase of excitatory postsynaptic potentials evoked 200 milliseconds later. These results suggest that a single burst of axonal stimulation produces a transient, spatially diffuse priming effect that prolonges responses to subsequent bursts, and that these altered responses trigger spatially restricted synaptic modifications. The similarity of the temporal parameters of the priming effect and the theta rhythm that dominates the hippocampal electroencephalogram (EEG) during learning episodes suggests that this priming may be involved in behaviorally induced synaptic plasticity.