Effects of Weak Environmental Magnetic Fields on the Spontaneous Bioelectrical Activity of Snail Neurons
Effects of Weak Environmental Magnetic Fields on the Spontaneous Bioelectrical Activity of Snail Neurons
复制标题
弱环境磁场对蜗牛神经元自发生物电活动的影响
DOI：
--
复制
发表时间：
2011
影响因子：
2.4
通讯作者：
M. Janahmadi
中科院分区：
文献类型：
--
作者：
M. K. Moghadam;M. Firoozabadi;M. Janahmadi
我们研究了在与当前环境暴露相关的磁通密度范围内，50赫兹磁场对陆螺神经元的动作电位(AP)、后超极化电位(AHP)和神经元兴奋性的影响。结果表明，当神经元暴露于不同磁通密度的磁场中时，神经元的兴奋性、AP放电频率和AHP幅度均有明显变化。这些效应似乎与暴露的强度、类型(单次和连续或重复和累积)和持续时间(18或20分钟)有关。极低频(ELF)磁场暴露以非单调的方式影响F1神经元细胞的兴奋性，通过干扰细胞膜的电生理特性来扰乱其正常特征和同步放电模式。我们的结果可以解释ELF磁场的作用机理和作用部位之一。磁场抑制效应的一个可能解释可能是通过抑制电压门控的钙通道而减少了钙内流。然而，在电压钳制条件下，具体的作用机制还需要进一步的研究。
We examined the effects of 50-Hz magnetic fields in the range of flux densities relevant to our current environmental exposures on action potential (AP), after-hyperpolarization potential (AHP) and neuronal excitability in neurons of land snails, Helix aspersa. It was shown that when the neurons were exposed to magnetic field at the various flux densities, marked changes in neuronal excitability, AP firing frequency and AHP amplitude were seen. These effects seemed to be related to the intensity, type (single and continuous or repeated and cumulative) and length of exposure (18 or 20 min). The extremely low-frequency (ELF) magnetic field exposures affect the excitability of F1 neuronal cells in a nonmonotonic manner, disrupting their normal characteristic and synchronized firing patterns by interfering with the cell membrane electrophysiological properties. Our results could explain one of the mechanisms and sites of action of ELF magnetic fields. A possible explanation of the inhibitory effects of magnetic fields could be a decrease in Ca2+ influx through inhibition of voltage-gated Ca2+ channels. The detailed mechanism of effect, however, needs to be further studied under voltage-clamp conditions.