Diffusion tensor imaging in neuropsychiatric systemic lupus erythematosus.
Diffusion tensor imaging in neuropsychiatric systemic lupus erythematosus.
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DOI：
10.1186/1471-2377-10-65
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发表时间：
2010-07-28
期刊：
影响因子：
2.6
通讯作者：
Roldan CA
中科院分区：
文献类型：
--
作者：
Jung RE;Caprihan A;Chavez RS;Flores RA;Sharrar J;Qualls CR;Sibbitt W;Roldan CA
神经精神系统性红斑狼疮（NPSLE）与发病率和死亡率增加有关。我们使用扩散张量成像（DTI）评估17名NPSLE患者、16名无NPSLE的SLE患者和20名年龄和性别匹配的对照组的白色异常。NPSLE患者与SLE和对照组患者在胼胝体、大钳左臂和左前放射冠的白色完整性方面存在显著差异。白色物质损伤的几种可能的机制进行了探讨，包括血管损伤，药物作用，血小板或纤维蛋白的大或微栓塞从利伯曼-萨克斯心内膜炎。
Neuropsychiatric systemic lupus erythematosus (NPSLE) is associated with increased morbidity and mortality. We used Diffusion Tensor Imaging (DTI) to assess white matter abnormalities in seventeen NPSLE patients, sixteen SLE patients without NPSLE, and twenty age- and gender-matched controls. NPSLE patients differed significantly from SLE and control patients in white matter integrity of the body of the corpus callosum, the left arm of the forceps major and the left anterior corona radiata. Several possible mechanisms of white matter injury are explored, including vascular injury, medication effects, and platelet or fibrin macro- or microembolism from Libman-Sacks endocarditis.