Meandering Down the Energy Landscape of Protein Folding: Are We There Yet?
Meandering Down the Energy Landscape of Protein Folding: Are We There Yet?
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DOI：
10.1016/j.bpj.2016.03.030
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发表时间：
2016-05-10
影响因子：
3.4
通讯作者：
Gai, Feng
中科院分区：
文献类型：
--
作者：
Abaskharon, Rachel M.;Gai, Feng
根据一项出版物指标判断，蛋白质折叠领域的活动在经历了长达十年的增长后，在过去五年中一直在下降。这种发展是否表明该领域正在日落，或者这种下降只是暂时的？在调查其景观的一小部分领土后，我们发现蛋白质折叠领域仍然相当活跃，并且从最近的实验研究中出现了许多重要的发现。然而，同样清楚的是，只有不断发展新的技术和方法，特别是那些能够解剖蛋白质折叠能量景观的细节和特征的技术和方法，才能推动这个古老的领域向前发展。
As judged by a single publication metric, the activity in the protein folding field has been declining over the past 5 years, after enjoying a decade-long growth. Does this development indicate that the field is sunsetting or is this decline only temporary? Upon surveying a small territory of its landscape, we find that the protein folding field is still quite active and many important findings have emerged from recent experimental studies. However, it is also clear that only continued development of new techniques and methods, especially those enabling dissection of the fine details and features of the protein folding energy landscape, will fuel this old field to move forward.