Plasma Superoxide Dismutase Activity and Mortality in Patients With Septic
Plasma Superoxide Dismutase Activity and Mortality in Patients With Septic
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DOI：
10.1097/ta.0b013e3181dbb289
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发表时间：
2010-12-01
影响因子：
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通讯作者：
Ritter, Cristiane
中科院分区：
文献类型：
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作者：
Guerreiro, Marcio Osorio;Petronilho, Fabricia;Ritter, Cristiane
背景：本研究的目的是确定血浆超氧化物歧化酶（SOD）活性与其他氧化参数相比，是否与脓毒症患者的死亡率有关。方法：对96例脓毒症患者进行前瞻性观察研究。研究纳入后立即和24小时后采集血样。然后我们测定血浆中硫代巴比妥酸活性物质、蛋白质羰基、SOD和过氧化氢酶活性的水平。结果：在非幸存者中，血浆羰基和SOD活性显著升高，而血浆硫代巴比妥酸活性物质和过氧化氢酶活性显著升高。SOD活性与急性生理和慢性健康评估II和多器官功能障碍评分显著相关。此外，与急性生理与慢性健康评估II相比，SOD活性在受体操作者特征曲线下呈现相似的区域，用于预测死亡率。D1和D2之间SOD活性降低25%或更多与更好的结果相关。结论：我们的数据为血浆SOD活性作为人类败血症的生物标志物提供了一些新的信息。
Background: The aim of this study was to determine whether plasma superoxide dismutase (SOD) activity, in comparison with other oxidative parameters, is associated with mortality in humans with septic.Methods: We conducted a prospective observational study including 96 patients with septic. Blood samples were collected immediately after study inclusion and 24 hours after. We then determined plasma levels of thiobarbituric acid reactive species, protein carbonyls, SOD, and catalase activities.Results: Plasma carbonyls and SOD activity, but not plasma thiobarbituric acid reactive species and catalase activity, were significantly higher in non-survivors. SOD activity significantly correlated with Acute Physiology and Chronic Health Evaluation II and Multiple Organ Dysfunction Score. In addition, SOD activity presented similar area under the receiver operator characteristic curve when compared with Acute Physiology and Chronic Health Evaluation II to predict mortality. A diminution of 25% or more on SOD activity between D1 and D2 was associated with a better outcome.Conclusion: Our data provide some new information on the use of plasma SOD activity as a biomarker in human sepsis.