Sarcopenia as a Prognostic Biomarker of Advanced Urothelial Carcinoma
Sarcopenia as a Prognostic Biomarker of Advanced Urothelial Carcinoma
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DOI：
10.1371/journal.pone.0115895
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发表时间：
2015-01-22
期刊：
影响因子：
3.7
通讯作者：
Koga, Fumitaka
中科院分区：
文献类型：
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作者：
Fukushima, Hiroshi;Yokoyama, Minato;Koga, Fumitaka
肉质减少是反映骨骼肌退行性丢失的一个新概念，是癌症恶病质的客观指标。我们探讨了它作为晚期尿路上皮癌(UC)患者预后生物标志物的作用。方法对88例有CT4和/或远处器官转移的UC患者进行回顾性研究。骨骼肌指数(SMI)是全身肌肉质量的一个指标，在诊断时从CT图像中测量。骨质疏松症的定义是
ObjectivesSarcopenia, a novel concept reflecting the degenerative loss of skeletal muscle mass, is an objective indicator of cancer cachexia. We investigated its role as a prognostic biomarker in advanced urothelial carcinoma (UC) patients.MethodsThis retrospective study consisted of 88 UC patients with cT4 and/or metastases to lymph nodes/distant organs. Skeletal muscle index (SMI), an indicator of whole-body muscle mass, was measured from computed tomography (CT) images at the diagnosis. Sarcopenia was defined as SMIs of