Adolescent versus adult onset and the development of substance use disorders in males
Adolescent versus adult onset and the development of substance use disorders in males
复制标题
DOI：
10.1016/s0376-8716(97)00154-3
复制
发表时间：
1998-01-01
影响因子：
4.2
通讯作者：
Tarter, RE
中科院分区：
文献类型：
--
作者：
Clark, DB;Kirisci, L;Tarter, RE
本研究通过比较成年男性 (n = 181) 和分为青少年发病组、成年早期发病组和成年晚期发病组的 SUD 对物质使用和相关障碍的模式、物质依赖发展的时间进程以及共病精神障碍的发生率，探讨青少年发病年龄对物质使用障碍 (SUD) 发展的影响。患有 SUD 的男性青少年样本 (n = 81) 也被纳入对照组。受试者是从社区干预计划中招募的，并参与半结构化访谈，并通过最佳估计方法确定诊断。与其他成年发病群体相比，青少年发病的成年人一生中大麻和致幻剂使用障碍的发生率更高，从第一次接触到依赖的时间更短，第一次和第二次依赖诊断之间的时间更短，并且破坏性行为障碍和重度抑郁症的发生率更高。青少年与青春期发病的成年人相似。虽然必须根据方法学限制来解释研究结果，但这些结果表明青少年发病的 SUD 是一种独特的亚型，涉及不同的物质，并且比成人发病的 SUD 发展更快。 (C) 1998 爱思唯尔科学爱尔兰有限公司
This study examines the influence of adolescent age of onset on the development of substance use disorders (SUD) by comparing adult males (n = 181) with SUD categorized into adolescent-onset, early-adult onset and late-adult onset groups on patterns of substance use and related disorders, time course of the development of substance dependence and rates of comorbid mental disorders. A sample of male adolescents (n = 81) with SUD was also included as a comparison group. The subjects were recruited from intervention programs in the community and participated in semistructured interviews with diagnoses determined by the best estimate method. Adolescent-onset adults, compared with other adult-onset groups, had higher lifetime rates of cannabis and hallucinogen use disorders, shorter times from first exposure to dependence, shorter times between the development of their first and second dependence diagnoses and higher rates of disruptive behavior disorders and major depression. Adolescents were similar to adolescent-onset adults. While the findings must be interpreted in light of methodological limitations, these results suggest that adolescent-onset SUD is a distinct subtype involving different substances and more rapid development than adult-onset SUD. (C) 1998 Elsevier Science Ireland Ltd.