Cartography of SARS‐CoV‐2 variants based on the susceptibility to therapeutic monoclonal antibodies
Cartography of SARS‐CoV‐2 variants based on the susceptibility to therapeutic monoclonal antibodies
复制标题
基于治疗性单克隆抗体敏感性的 SARS-CoV-2 变体制图
DOI：
10.1002/jmv.28275
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发表时间：
2022
影响因子：
12.7
通讯作者：
Furuse Yuki
中科院分区：
文献类型：
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作者：
Furuse Yuki
严重急性呼吸综合征冠状病毒2型（SARS-CoV-2）变异体之间表型关系的全面研究很少。在这里，这项研究展示了从对12种治疗性单克隆抗体的敏感性的角度来看，SARS-CoV-2野生型菌株和14种变体是如何相似或不同的。α变体与野生型菌株接近，而β、γ和δ变体与野生型菌株不同。这张地图突出了奥密克隆变体的独特属性。有趣的是，Omicron变种的亚系BA.1、BA.2和BA.4/5在地图上有很大的不同。
A comprehensive picture of a phenotypic relationship among severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) variants has been poorly studied. Here, this study presents cartography showing how the wild‐type strain of SARS‐CoV‐2 and 14 variants are alike or different from the perspective of the susceptibility to 12 therapeutic monoclonal antibodies. The Alpha variant is close to the wild‐type strain, whereas the Beta, Gamma, and Delta variants diverge from the wild‐type. The map highlights the very unique property of the Omicron variant. Interestingly, sublineages of the Omicron variants, BA.1, BA.2, and BA.4/5, differ substantially in the cartography.