Intratumoral Vascular Shunting: Biomarker of Clinical Outcome and Source of Circulating Tumor Cells?
Intratumoral Vascular Shunting: Biomarker of Clinical Outcome and Source of Circulating Tumor Cells?
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DOI：
10.1097/coc.0000000000000145
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发表时间：
2015-12
期刊：
影响因子：
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通讯作者：
A. Deipolyi;A. Zhu;R. Oklu
中科院分区：
文献类型：
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作者：
A. Deipolyi;A. Zhu;R. Oklu
预测哪些患者将受益于放射性栓塞仍然是一个挑战，因为可靠的预后指标尚未确定。异常的肿瘤血管解剖结构不仅会影响癌症治疗穿透肿瘤的能力，而且还可能有助于病变的转移潜力。具体来说，肿瘤内血管分流可以允许循环肿瘤细胞通过绕过毛细血管床进入体内的远端部位来启动转移。在这里，我们描述了肿瘤血管生成是如何发生的，以及肿瘤内血管分流是如何形成的。
Predicting which patients will benefit from radioembolization remains a challenge, as reliable prognostic indicators are not defined. Abnormal tumor vascular anatomy could not only impact the ability of cancer therapies to penetrate tumors, but may also contribute to a lesion’s metastatic potential. Specifically, intratumoral vascular shunts could allow circulating tumor cells to initiate metastases by allowing them to gain access to distant sites in the body, bypassing capillary beds. Here, we describe how tumoral angiogenesis occurs and how intratumoral vascular shunts may form.