Proton magnetic resonance spectroscopy of the frontal lobe and cerebellar vermis in children with a mood disorder and a familial risk for bipolar disorders
Proton magnetic resonance spectroscopy of the frontal lobe and cerebellar vermis in children with a mood disorder and a familial risk for bipolar disorders
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DOI：
10.1089/104454603322724931
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发表时间：
2003-12-01
影响因子：
1.9
通讯作者：
Strakowski, SM
中科院分区：
文献类型：
--
作者：
Cecil, KM;DelBello, MP;Strakowski, SM
目的：很少有研究探讨可能与儿童双相情感障碍相关的神经化学异常。本研究的目的是使用磁共振波谱法来评估患有心境障碍和双相情感障碍家族风险的儿童中与双相情感障碍有关的几个脑区。我们假设这些孩子与父母没有精神疾病的健康孩子相比，会表现出神经化学差异。具体来说，减少N-乙酰天冬氨酸（NAA）和肌酸和磷酸肌酸（Cr）的前额叶皮层和小脑蚓部将反映受损的神经元功能和细胞代谢，和升高的肌醇（mI）将反映受损的磷酸肌醇代谢，可能代表神经生理学变化的早期标志物，可能是双相情感障碍的发展基础。采用华盛顿大学圣路易斯分校儿童情感障碍和精神分裂症量表，对年龄（8-12岁）、种族、性别、教育和坦纳分期相匹配的心境障碍儿童和至少一名双相情感障碍父母（n = 9）和健康儿童（n = 10）进行评估。质子磁共振波谱采集使用8毫升体积内额叶皮质，额叶白色物质，小脑蚓部。计算代谢物比率（NAA/Cr，胆碱（Cho）/Cr，mI/Cr，NAA/Cho，NAA/mI和Cho/mI）和浓度（NAA，Cr，Cho和mI），并进行组间比较。在儿童的情绪障碍的额叶皮质显示升高的MI浓度水平，约16%增加，与健康childhes.Conclusions：在成人双相情感障碍，额叶皮质和小脑蚓部内的神经化学异常的发现相似，存在于这个初步比较的儿童的情绪障碍和家族性双相情感障碍的风险。需要更大的样本量来复制这些发现。
Objective: Few studies have examined the neurochemical abnormalities that might be associated with pediatric bipolar disorder. The aim of this study was to use magnetic resonance spectroscopy to evaluate several brain regions implicated in bipolar disorder in children with a mood disorder and a familial risk for bipolar disorder. We hypothesized that these children would exhibit neurochemical differences compared with healthy children of parents without a psychiatric disorder. Specifically, decreased N-acetylaspartate (NAA) and creatine and phosphocreatine (Cr) of the prefrontal cortex and cerebellar vermis would reflect impairments in neuronal function and cellular metabolism, and elevated myo-inositol (mI) would reflect impaired phosphoinositide metabolism, potentially representing early markers of neurophysiologic changes that might underlie the development of bipolar disorder.Methods: Children with a mood disorder and at least one parent with bipolar disorder (n = 9) and healthy children (n = 10) group matched for age (8-12 years), race, sex, education, and Tanner stage were evaluated using the Washington University in St. Louis Kiddie Schedule for Affective Disorders and Schizophrenia. Proton magnetic resonance spectroscopy was acquired using 8-cc volumes within the frontal cortex, frontal white matter, and the cerebellar vermis. Metabolite ratios (NAA/Cr, cholines (Cho)/Cr, mI/Cr, NAA/Cho, NAA/mI, and Cho/mI) and concentrations (NAA, Cr, Cho, and mI) were calculated and compared between groups.Results: The trend in concentration levels of NAA and Cr was approximately 8% lower for children with a mood disorder than healthy children within the cerebellar vermis. The frontal cortex in children with a mood disorder revealed elevated mI concentration levels, approximately 16% increased, compared with healthy children.Conclusions: Similar to findings in adults with bipolar disorders, neurochemical abnormalities within the frontal cortex and the cerebellar vermis were present in this preliminary comparison of children with a mood disorder and a familial risk for bipolar disorder. Larger sample sizes are needed to replicate these findings.