Increasing Incidence of Oral Tongue Squamous Cell Carcinoma in Young White Women, Age 18 to 44 Years
Increasing Incidence of Oral Tongue Squamous Cell Carcinoma in Young White Women, Age 18 to 44 Years
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DOI：
10.1200/jco.2010.31.7883
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发表时间：
2011-04-10
影响因子：
45.3
通讯作者：
Chera, Bhishamjit S.
中科院分区：
文献类型：
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作者：
Patel, Sagar C.;Carpenter, William R.;Chera, Bhishamjit S.
目的评估 18 至 44 岁年轻白人女性口腔鳞状细胞癌 (OCSCC) 和口腔舌鳞状细胞癌 (OTSCC) 的发病率。患者和方法我们分析了 1975 年至 2007 年国家癌症研究所监测、流行病学和最终结果 (SEER) 项目中 OCSCC 和 OTSCC 的发病率和生存数据。检查了三个队列：所有年龄、年龄 18 至 44 岁（即“年轻”）和年龄 > 44 岁。个人按性别和/或种族进行分层。计算百分比变化（PC）和年度百分比变化（APC）。进行连接点回归分析以检查趋势差异。结果总体而言，所有年龄段的 OCSCC 发病率均呈下降趋势。然而，年轻白人女性的发病率正在增加（PC，34.8；APC，2.2；P < .05）。除 18 至 44 岁组外，所有年龄段的 OTSCC 发病率均呈下降趋势（PC，28.8；APC，1.8；P < .05）。年轻白人的 OTSCC 发病率呈上升趋势（白人女性：PC，111.3；APC，4；P < .05；年轻白人男性：PC，43.7；APC，1.6；P < .05）。与年轻白人男性相比，年轻白人女性的 OTSCC APC 显着更高 (P = .007)。此外，口腔所有其他亚部位的鳞状细胞癌发生率正在下降。非白人 OCSCC 和 OTSCC 的发病率有所下降。 18 至 44 岁的白人和 44 岁以上的个体的病因特异性生存率相似。结论 OTSCC 在 18 至 44 岁的年轻白人中正在增加，特别是在白人女性中。年轻的白人女性可能是新出现的头颈癌患者群体。
PurposeTo evaluate the incidence of oral cavity squamous cell carcinoma (OCSCC) and oral tongue squamous cell carcinoma (OTSCC) in young white women, age 18 to 44 years.Patients and MethodsWe analyzed incidence and survival data from the Surveillance, Epidemiology and End Results (SEER) Program of the National Cancer Institute from 1975 to 2007 for OCSCC and OTSCC. Three cohorts were examined: all ages, age 18 to 44 years (ie, "young"), and age > 44 years. Individuals were stratified by sex and/or race. Percentage change (PC) and annual percentage change (APC) were calculated. Joinpoint regression analyses were performed to examine trend differences.ResultsOverall, incidence of OCSCC was decreasing for all ages. However, incidence was increasing for young white women (PC, 34.8; APC, 2.2; P < .05). Incidence of OTSCC was decreasing for all ages except in the age 18 to 44 years group (PC, 28.8; APC, 1.8; P < .05). Young white individuals had increasing incidence trends of OTSCC (white women: PC, 111.3; APC, 4; P < .05; young white men: PC, 43.7; APC, 1.6; P < .05). The APC of OTSCC was significantly greater in young white women compared with that in young white men (P = .007). Furthermore, incidence of SCC in all other subsites of the oral cavity was decreasing. Nonwhites had a decreasing incidence of OCSCC and OTSCC. Cause-specific survival was similar among whites age 18 to 44 and individuals older than age 44 years.ConclusionOTSCC is increasing among young white individuals age 18 to 44 years, particularly among white women. Young white women may be a new, emerging head and neck cancer patient population.