Fibroblast growth factor receptor-dependent morphogenesis of the Drosophila mesoderm
Fibroblast growth factor receptor-dependent morphogenesis of the Drosophila mesoderm
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DOI：
10.1098/rstb.2000.0625
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发表时间：
2000-07-29
期刊：
影响因子：
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通讯作者：
Leptin, M
中科院分区：
文献类型：
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作者：
Wilson, R;Leptin, M
果蝇成纤维细胞生长因子受体无心和无气是中胚层和气管系统形态发生所必需的。在这篇文章中，我们讨论了一些与这些组织的形态发生有关的问题，并推测了潜在机制的一些鲜为人知的方面。到目前为止，配基还没有被确定为无情，但在呼吸困难的情况下，配基在某些情况下可能起到趋化信号的作用。我们认为，远距离趋化信号的释放不太可能在中胚层的形态发生中起作用。相反，我们认为，中胚层从内陷上皮到外胚层上铺开的单层细胞的变化可能是中胚层细胞试图最大限度地接触外胚层的结果。目前还不清楚成纤维细胞生长因子受体的激活如何影响细胞行为并导致细胞运动。这种信号可能只是允许的，导致细胞活动，或者它可以作为已经活动的细胞的方向信号，或者可能同时提供这两种功能。此外，目前还不清楚信号转导如何与形态变化相关联。转录靶标的激活似乎不太可能是细胞迁移所必需的，而且成纤维细胞生长因子信号可能对细胞骨架有直接影响，而不是激活丝裂原激活的蛋白激酶级联反应。DOF编码成纤维细胞生长因子信号转导所需的一种细胞质蛋白，对其功能的分析可能提供对这些问题的洞察。
The Drosophila fibroblast growth factor (FGF) receptors Heartless and Breathless are required for the morphogenesis of the mesoderm and the tracheal system. In this article we discuss a number of questions relating to the morphogenesis of these tissues and speculate on poorly understood aspects of the underlying mechanisms. As yet a ligand has not been identified for Heartless, but in the case of Breathless the ligand may in some situations act as a chemotactic signal. We consider it unlikely that release of a distant chemotactic signal plays a role in the morphogenesis of the mesoderm. Instead we propose that the change in the mesoderm from an invaginated epithelium to a single layer of cell spread out on the ectoderm could be a result of the mesodermal cells trying to maximize their contact with the ectoderm. Exactly how the activation of the FGF receptors affects cell behaviour and leads to cell movement is not understood. The signal could simply be permissive, causing cells to become motile, or it could act as a directional signal for cells that are already motile, or perhaps provide both functions. Furthermore, it is unclear how signal transduction is coupled to morphological change. It seems unlikely that activation of transcription targets is essential for cell migration and it is possible that FGF signaling may have a direct effect on the cytoskeleton independent of the activation of the mitogen-activated protein kinase cascade. Analysis of the function of dof, which encodes a cytoplasmic protein required for FGF signal transduction may provide an insight into these issues.