Differential expression of a novel serine protease homologue in squamous cell carcinoma of the head and neck.
Differential expression of a novel serine protease homologue in squamous cell carcinoma of the head and neck.
复制标题
DOI：
10.1054/bjoc.2000.1586
复制
发表时间：
2001-01
影响因子：
8.8
通讯作者：
Schuller DE
中科院分区：
文献类型：
--
作者：
Lang JC;Schuller DE
利用代表性差异分析研究了头颈部鳞状细胞癌与匹配的正常组织之间的差异基因表达。使用这种方法，分离出一个新基因 DESC1。 DESC1 与丝氨酸蛋白酶超家族具有很强的同一性。原发性鳞状细胞癌和匹配的正常组织之间的DESC1表达的比较表明，与匹配的正常组织标本相比，11/12 SCC组织标本中DESC1表达水平降低或不存在。组织特异性表达研究进一步表明，DESC1 表达只能在头颈组织、皮肤、前列腺和睾丸中检测到。细胞系研究表明 DESC1 表达具有上皮特异性。染色体定位研究表明，DESC1 位于 4 号染色体长臂上的 q12-13 位置。 © 2001 癌症研究运动 http://www.bjcancer.com
Differential gene expression between squamous cell carcinoma of the head and neck and matched normal tissue was studied by utilizing Representational Difference Analysis. Using this methodology, a novel gene, DESC1 was isolated. DESC1 possesses strong identity to the serine protease super-family. Comparison of DESC1 expression between primary squamous cell carcinoma and matched normal tissue shows that the level of DESC1 expression is reduced or absent in 11/12 SCC tissue specimens when compared to specimens of matched normal tissue. Tissue-specific expression studies further show that DESC1 expression can only be detected in tissues derived from the head and neck, and in skin, prostate and testes. Cell line studies demonstrate that DESC1 expression is epithelial-specific. Chromosomal localization studies indicate that DESC1 is located on the long arm of chromosome 4 at position q12–13. © 2001 Cancer Research Campaign http://www.bjcancer.com
登录
查看更多内容
影响因子：
2.6
作者：
Lang, JC;Tobin, EJ;Weghorst, CM
通讯作者：
Weghorst, CM
影响因子：
8
作者：
Loughran, O;Clark, LJ;Parkinson, EK
通讯作者：
Parkinson, EK
影响因子：
4.8
作者：
Yamaoka, K;Masuda, K;Yasuoka, S
通讯作者：
Yasuoka, S
DOI：
10.1073/pnas.93.12.6025
发表时间：
1996-06-11
影响因子：
11.1
作者：
Diatchenko, L;Lau, YFC;Siebert, PD
通讯作者：
Siebert, PD
DOI：
10.1002/(sici)1097-0347(199803)20:2
发表时间：
1998-03-01
影响因子：
2.9
作者：
Bockmuhl, U;Wolf, G;Petersen, I
通讯作者：
Petersen, I