Access to functionalized 4-benzylidene-4H-benzo[d][1,3]thiazines via tandem addition-cyclization/cross-coupling reactions
Access to functionalized 4-benzylidene-4H-benzo[d][1,3]thiazines via tandem addition-cyclization/cross-coupling reactions
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通过串联加成环化/交叉偶联反应获得功能化的4-亚苄基-4H-苯并[d][1,3]噻嗪
DOI：
10.1016/j.tet.2012.03.098
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发表时间：
2012-05-27
期刊：
影响因子：
2.1
通讯作者：
Peng, Yiyuan
中科院分区：
文献类型：
--
作者：
Ding, Qiuping;Liu, Xianjin;Peng, Yiyuan
各种2-炔基苯胺与CS2的串联加成-环化反应在温和条件下导致2-巯基-4-亚苄基-4H-苯并[d][1，3]噻嗪的形成。该反应显示出中等至优异的产率，并且具有高度的区域特异性，并且通过6-exo-dig S-环化仅生成六元环。该反应可以通过Cut催化的交叉偶联和还原偶联反应转化为高度官能化的4-亚苄基-4H-苯并[d][1，3]噻嗪。(C)2012爱思唯尔有限公司版权所有。
Tandem addition-cyclization reactions of various 2-alkynylbenzenamines with CS2 lead to the formation of 2-mercapto-4-benzylidene-4H-benzo[d][1,3]thiazines under mild conditions. The reactions showed moderate to excellent yields and were highly regiospecific, and only the six-membered ring was generated via 6-exo-dig S-cyclization. The reaction can be transferred to highly functionalized 4-benzylidene-4H-benzo[d][1,3]thiazines via Cut-catalyzed crossing-coupling and reductive coupling reactions. (C) 2012 Elsevier Ltd. All rights reserved.