Involvement of glycation and oxidative stress in diabetic macroangiopathy
Involvement of glycation and oxidative stress in diabetic macroangiopathy
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DOI：
10.2337/diab.45.3.s81
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发表时间：
1996-07-01
期刊：
影响因子：
7.7
通讯作者：
Kayanoki, Y
中科院分区：
文献类型：
--
作者：
Taniguchi, N;Kaneto, H;Kayanoki, Y
在糖尿病条件下，美拉德反应促进活性氧的产生，Cu、zn -超氧化物歧化酶等抗氧化酶活性降低，导致氧化应激显著增加，氧化应激攻击DNA、脂质和蛋白质，也被认为参与糖尿病并发症的发病机制，包括大血管病变的进展。众所周知，平滑肌细胞（SMCs）的增殖与大血管病变的进展有关，并受几种生长因子的调节。SMCs至少有三种丝裂原，血小板衍生生长因子（PDGF）、成纤维细胞生长因子和肝素结合表皮生长因子样生长因子（HB-EGF），已知由SMCs本身产生，被认为是糖尿病、HB-EGF、HB-EGF等大血管病变进展中最有效的生长因子。3-脱氧葡萄糖酮（3-DG）是糖基化反应中一个主要且高活性的中间体，在转录水平上受3-DG的调控，其诱导作用似乎是由3-DG产生的活性氧增加引发的，综上所述，糖尿病条件下的糖基化反应可能通过增强HB-EGF的基因表达与糖尿病大血管病变的发病机制高度相关。
Under diabetic conditions, the Maillard reaction facilitates the production of reactive oxygen species, and the activity of antioxidant enzymes such as Cu,Zn-superoxide dismutase is decreased, resulting in a remarkable increase of oxidative stress, The oxidative stress attacks DNA, lipids, and proteins and is also thought to be involved in the pathogenesis of diabetic complications, including the progression of macroangiopathy, Proliferation of smooth muscle cells (SMCs) is known to be associated with progression of macroangiopathy and is modulated by several growth factors, At least three mitogens for SMCs, platelet-derived growth factor (PDGF), fibroblast growth factor, and heparin-binding epidermal growth factor-like growth factor (HB-EGF), are known to be produced by SMCs themselves and are considered to be the most potent growth factors in the progression of macroangiopathy as seen in diabetes, HB-EGF, but not PDGF, is regulated at the transcriptional level by 3-deoxyglucosone (3-DG), a major and highly reactive intermediate in the glycation reaction, The induction seems to be triggered by the increase of reactive oxygen species produced by 3-DG, Taken together, glycation reactions under diabetic conditions may be highly associated with the pathogenesis of diabetic macroangiopathy by enhancing the gene expression of HB-EGF.