MEASUREMENTS OF IRON STATUS IN PATIENTS WITH CHRONIC HEPATITIS
MEASUREMENTS OF IRON STATUS IN PATIENTS WITH CHRONIC HEPATITIS
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DOI：
10.1016/0016-5085(92)90339-z
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发表时间：
1992-06-01
期刊：
影响因子：
29.4
通讯作者：
BACON, BR
中科院分区：
文献类型：
--
作者：
DIBISCEGLIE, AM;AXIOTIS, CA;BACON, BR
对80例慢性病毒性肝炎患者进行了铁超载的筛查。36%的患者血清铁值升高；30%的男性和8%的女性血清铁蛋白水平高于正常水平。对另外28例有肝组织铁含量测定的慢性肝炎患者进行评估，以研究铁超载与慢性肝炎的相关性。尽管46%的患者血清铁、铁蛋白或转铁蛋白饱和水平升高，但只有4例患者的肝铁浓度升高，其中只有2例患者的肝铁指数在遗传性血色素沉着症(>；2.0)的范围内。在这些患者中，血清天冬氨酸转氨酶活性与血清铁蛋白水平相关，这表明血清中铁蛋白和铁的水平升高是因为它们从与坏死相关的肝细胞储存库中释放出来。因此，对于怀疑遗传性血色沉着症的慢性肝炎患者，应进行肝活检，测定肝铁含量，计算肝铁指数，以确定诊断。
Eighty patients with chronic viral hepatitis were screened for evidence of iron overload. Elevated serum iron values were noted in 36% of cases; serum ferritin values were above normal in 30% of men and 8% of women. Twenty-eight additional patients with chronic hepatitis for whom liver tissue was available for determination of iron content were evaluated to study the significance of iron overload in association with chronic hepatitis. Although 46% had elevated serum iron, ferritin, or transferrin-saturation levels, the hepatic iron concentration was elevated in only four cases, and the hepatic iron index was in the range for hereditary hemochromatosis (> 2.0) in only two of these. Serum aspartate aminotransferase activities correlated with serum ferritin levels in these patients, suggesting that ferritin and iron levels were increased in serum because of their release from hepatocellular stores associated with necrosis. Thus, in patients with chronic hepatitis in whom hereditary hemochromatosis is suspected, a liver biopsy should be performed with quantitation of hepatic iron and calculation of the hepatic iron index to confirm the diagnosis.