Compositional differences of LDL particles in normal subjects with LDL subclass phenotype A and LDL subclass phenotype B
Compositional differences of LDL particles in normal subjects with LDL subclass phenotype A and LDL subclass phenotype B
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DOI：
10.1161/01.atv.16.8.1040
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发表时间：
1996-08-01
影响因子：
8.7
通讯作者：
Hokanson, JE
中科院分区：
文献类型：
--
作者：
Capell, WH;Zambon, A;Hokanson, JE
通过梯度凝胶电泳测定，在心肌梗死患者中发现小LDL颗粒占优势（亚类表型B）。尽管在表型A和B颗粒的物理差异，在这些表型的颗粒的脂质组成的差异还没有被报道在一个共同的人口的配偶和女性。本研究使用脂质/载脂蛋白B的比例，分析了70名健康受试者的密度梯度超离心分离的每个LDL颗粒的脂质量。相对于载脂蛋白B，发现表型B受试者的LDL颗粒含有较少的游离胆固醇（0.391+/-0.05与0.465+/-0.05;平均值+/-SD; P
A predominance of small LDL particles (subclass phenotype B), as determined by gradient-gel electrophoresis is found among patients with myocardial infarction. Despite physical differences in phenotype A and B particles, differences in lipid composition of particles in these phenotypes have yet to be reported in an unselected population of mates and females. The present study used lipid/apoB ratios to analyze the amount of lipid per LDL particle, isolated by density-gradient ultracentrifugation, in 70 healthy subjects. Relative to apoB, the LDL particles from phenotype B subjects were found to contain less free cholesterol (0.391+/-0.05 versus 0.465+/-0.05; mean+/-SD; P